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Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice.

The 5^th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.

• Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
• Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
• Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

• Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.
• Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors.
• 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis.
• New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place.
• In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

Fetal and Neonatal Physiology, 2-Volume Set

Section I - Genetics and Embryology

1. Basic Genetic Principles
2. Prenatal Diagnosis
3. Basic Embryology
4. Regulation of Embryogenesis
5. The Extracellular Matrix in Development
6. Stem Cell Biology
7. Apoptotic Cell Death
8. Angiogenesis
9. Epigenetics

Section II - Placenta and Intrauterine Environment

10. Placental Development
11. Regulation of the Placental Circulation
12. Mechanisms of Transfer Across the Human Placenta
13. Endocrine and Paracrine Function of the Human Placenta
14. Fetal and Maternal Responses to Intrauterine Infection
15. Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance
16. Physiologic Effects of Multiple Pregnancy on Mother and Fetus
17. Placental function in intrauterine growth restriction

Section III - Developmental Pharmacology and Pharmacokinetics

18. Basic Pharmacologic Principles
19. Principles of Pharmacokinetics
20. Physicochemical and Structural Properties Regulating Placental Drug Transfer
21. Pharmacogenetics
22. Drug Distribution in Fetal Life
23. Drug Transfer During Breastfeeding

Section IV - Intrauterine and Postnatal Growth

24. Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
25. Endocrine Factors Affecting Neonatal Growth
26. Human Milk Composition and Function in the Infant
27. Physiology of Lactation

Section V - Perinatal Iron, Mineral, and Vitamin Metabolism

28. Fetal and Neonatal Iron Metabolism
29. Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
30. Zinc in the Fetus and Neonate
31. Vitamin A Metabolism in the Fetus and Neonate
32. Vitamin E Metabolism in the Fetus and Newborn Infant
33. Vitamin K Metabolism in the Fetus and Neonate

Section VI - Lipid Metabolism

34. Maternal-Fetal Transfer of Lipid Metabolites
35. Brown Adipose Tissue: Development and Function
36. Lipids as an Energy Source for the Premature and Full-Term Neonate
37. Ketone Body Production and Metabolism in the Fetus and Neonate
38. Long-Chain Fatty Acids in the Developing Retina and Brain

Section VII - Carbohydrate Metabolism

39. Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn
40. Carbohydrate Metabolism During Pregnancy
41. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
42. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
43. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development

Section VIII - Protein Metabolism

44. General Concepts of Protein Metabolism
45. Fetal Requirements and Placental Transfer of Nitrogenous Compounds

Section IX - Thermoregulation

46. Temperature Control in Newborn Infants
47. Responses of the Fetus and Neonate to Hypothermia

Section X - Skin

48. Structure and Development of Skin and Cutaneous Appendages
49. Physiologic Development of the Skin

Section XI - Fetal and Neonatal Cardiovascular Physiology

50. Cardiovascular Development
51. Developmental Electrophysiology in the Fetus and Neonate
52. Developmental Biology of the Pulmonary Vasculature
53. Development of the Gastrointestinal Circulation in the Fetus and Newborn
54. Physiology of Congenital Heart Disease in the Neonate
55. Neural Regulation of Blood Pressure During Fetal and Newborn Life
56. Developmental Effects on Fetal Circulation
57. Mechanisms Regulating