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Updated in light of recent research findings on fertilization, implantation and early pregnancy, this new edition combines the expertise of a wide range of internationally renowned authors to produce an authoritative, multidisciplinary approach to the management of first-trimester complications. Several international guidelines and consensus statements have been released since publication of the first edition and this has stimulated new focussed research questions that are addressed. The book's key recommendations provide clinicians with the tools to improve the patient's experience of the management of first-trimester complications. By combining essential elements of scientific research and clinical care, Early Pregnancy continues to set a benchmark for evidence-based management and will be essential reading for obstetricians, gynaecologists, neonatologists, ultrasonographers, and nurses seeking an understanding of the reproductive science of early pregnancy.

Early Pregnancy

1. Endometrial development and gene expression Alejandro Rincon, Maria Ruiz-Alonso, Patricia Diaz-Gimeno, Felipe Vilella and Carlos Simon; 2. Decidualization and recurrent miscarriage Nick Macklon and Jan J. Brosens; 3. Hemochorial development Graham J. Burton and Eric R. M. Jauniaux; 4. Implantation Kelly Pagidas and Errol R. Norwitz; 5. Early placental development and its disorders Kathleen A. Pennington, Lindsey B. Beffa and Danny J. Schust; 6. Meiosis and the embryo Tiffany Oliver; 7. Environmental toxicants and reproduction Clara H. Jeong, Changqing Zhou and Jodi A. Flaws; 8. Thyroid physiology and early pregnancy Coes Repelaer van Driel-Delprat, Eveline W. C. M. van Dam and Cornelius B. Lambalk; 9. Mullerian duct development Maribel Acien and Pedro Acien; 10. Candidate genes for pregnancy loss Evica Rajcan-Separovic; 11. Antiphospholipid antibodies and reproduction Lisa R. Sammaritano; 12. Defining recurrent pregnancy loss Astrid Marie Kolte, Mariette Goddijn and Mary D. Stephenson; 13. Guidelines on the diagnosis and management of miscarriage Caroline E. Overton and Kate O'Brien; 14. The value of early pregnancy units Roy G. Farquharson; 15. Investigation of recurrent miscarriage Feroza Dawood, Roy G. Farquharson and Mary D. Stephenson; 16. Designing and optimizing treatment trials for recurrent pregnancy loss Myrthe van Dijk, Madelon van Wely and Mariette Goddijn; 17. Risk-factors for first trimester miscarriage Ruth Bender-Atik, Barbara E. Hepworth-Jones and Pat Doyle; 18. Tubal ectopic pregnancy and pregnancy of unknown location Emma Kirk; 19. Non-tubal ectopic pregnancy Dimitrios Mavrelos and Davor Jurkovic; 20. Ultrasound to diagnose and predict early pregnancy outcome Cecilia Bottomley; 21. Three-dimensional virtual reality in early pregnancy Melek Rousian, Niek Exalto, A. H. J. Koning and Eric A. P. Steegers; 22. Molar pregnancy Jemma Johns and Eric R. M. Jauniaux; 23. Role of miscarriage evaluation Shweta Bhatt and Mary D. Stephenson; 24. Inherited thrombophilia and early pregnancy Thijs E. van Mens and Saskia Middeldorp; 25. Immunotherapy and recurrent pregnancy loss Anita Kuriya and William M. Buckett; 26. Progesterone use in early pregnancy Hoda Harb and Arri Coomarasamy; 27. Vanishing twin syndrome and long term outcome Anja Pinborg; 28. Obesity and early pregnancy Christina E. Boots and Kelle H. Moley; 29. Chronic endometritis and reproduction Dana B. McQueen and Mary D. Stephenson; 30. Miscarriage after in-vitro fertilization Jonathan D. Kort and Ruth Bunker Lathi; 31. HLA associations and recurrent pregnancy loss Henriette Svarre Nielsen and Thomas Vauvert F. Hviid; 32. Midtrimester pregnancy loss Kelly M. McNamee and Roy G. Farquharson.