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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients.* A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease* An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies* Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics* Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs* Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Holland-Frei Cancer Medicine, m. 1 Buch, m. 1 Online-Zugang, 2 Teile

List of contributors xiPreface xxviiAcknowledgments xxixPart 1: INTRODUCTION1 Cardinal manifestations of cancer 3James F. Holland, Waun Ki Hong,DonaldW. Kufe, Robert C. Bast Jr.,William N. Hait, Raphael E. Pollock, and Ralph R.Weichselbaum2 Biological hallmarks of cancer 7Douglas Hanahan and Robert A.WeinbergPart 2: TUMOR BIOLOGY3 Molecular biology, genomics, proteomics, and mouse models of human cancer 19Srinivas R. Viswanathan,David A. Tuveson, and Matthew Meyerson4 Oncogenes 47Marco A. Pierotti, Milo Frattini, Francesca Molinari, Gabriella Sozzi, and Carlo M. Croce5 Tumor suppressor genes 67David Cosgrove, Ben Ho Park, and Bert Vogelstein6 Epigenetic contributions to human cancer 85James G. Herman and Stephen B. Baylin7 Cancer genomics and evolution 93William P. D. Hendricks, Aleksandar Sekulic, Alan H. Bryce, Muhammed Murtaza, Pilar Ramos, and Jeffrey M. Trent8 Chromosomal aberrations in cancer 115David J. VanderWeele, Megan E. McNerney, and Michelle M. Le Beau9 MicroRNA expression in cancer 131Serge Patrick Nana-Sinkam, Mario Acunzo, and Carlo M. Croce10 Aberrant signaling pathways in cancer 137Luca Grumolato and Stuart A. Aaronson11 Differentiation therapy 147Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and Zhu Chen12 Cancer stem cells 159Yadwinder S. Deol, Jill Granger, and Max S.Wicha13 Cancer and cell death 167John C. Reed14 Cancer cell immortality: targeting telomerase 179Ilgen Mender, Zeliha Gunnur Dikmen,Woodring E. Wright, and JerryW. Shay15 Cancer metabolism 187Natalya N. Pavlova and Craig B.Thompson16 Modeling therapy of late or early-stage metastatic disease in mice 199Robert S. Kerbel, Marta Paez-Ribes, ShanMan, Ping Xu, Eric Guerin,William Cruz-Munoz, and John M. L. Ebos17 Tumor angiogenesis 207John V. Heymach, Amado Zurita-Saavedra, Scott Kopetz, Tina Cascone, and Monique NilssonPart 3: QUANTITATIVE ONCOLOGY18 Cancer bioinformatics 233John N.Weinstein19 Systems biology and genomics 247Saima Hassan, Laura M. Heiser, and JoeW. Gray20 Statistical innovations in cancer research 255J. Jack Lee and Donald A. Berry21 Biomarker-based clinical trial design in the era of genomic medicine 271Richard Simon and Martine Piccart-Gebhart22 Clinical informatics 277Edward P. AmbinderPart 4: CARCINOGENESIS23 Chemical carcinogenesis 287Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris24 Endocrine and genetic bases of hormone-related cancers 307Leslie Bernstein, Xia Pu, and Jian Gu25 Ionizing radiation 321David J. Grdina26 Ultraviolet radiation carcinogenesis 327James E. Cleaver, Susana Ortiz-Urda, Radhika Gulhar, Sarah T. Arron, Lionel Brookes 3rd, and David L.Mitchell27 Inflammation and cancer 333Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and Michael Karin28 RNA tumor viruses 341Robert C. Gallo and Marvin S. Reitz29 Herpesviruses 353Jeffrey I. Cohen30 Papillomaviruses and cervical neoplasia 361Michael F. Herfs, Martin C. Chang, and Christopher P. Crum31 Hepatitis viruses and hepatoma 367HongyangWang, Guangwen Cao, Jing Fu, and Guishuai Lv32 Parasites 373Mervat Z. El Azzouni and Radwa G. DiabPart 5: EPIDEMIOLOGY, PREVENTION AND DETECTION33 The burden of cancer worldwide: current and future perspectives 383Jacques Ferlay, Christopher P.Wild, and Freddie Bray34 Cancer epidemiology 399XifengWu, Xia Pu, Stephanie C. Melkonian, and Margaret R. Spitz35 Behavioral approaches to cancer prevention 407Errol J. Philip and Jamie S. Ostroff36 Diet and nutrition in the etiology and prevention of cancer 415Steven K. Clinton, Elizabeth M. Grainger, and Edward L. Giovannucci37 Chemoprevention of cancer 433William N.William Jr.,Waun Ki Hong, and Scott M. Lippman38 Cancer screening and early detection 439OtisW. BrawleyPart 6: CLINICAL DISCIPLINES39 Nexgen pathology: predicting clinical course and targeting disease causation 459Carlos Cordon-Cardo and Adolfo Firpo-Betancourt40 Molecular diagnostics in cancer 469Roshni D. Kalachand, Bryan T. Hennessy, Robert C. Bast Jr., and Gordon B. Mills41 Principles of imaging 481Lawrence H. Schwartz42 Interventional radiology for the cancer patient 483JudyU. Ahrar, Michael J. Wallace, and Rony Avritscher43 Principles of surgical oncology 491Mark Bloomston, Kenneth K. Tanabe, Raphael E. Pollock, and Donald L. Morton (deceased)44 Principles of radiation oncology 503Philip P. Connell and Ralph R.Weichselbaum45 Principles of medical oncology 511WilliamN. Hait, James F. Holland, Emil Frei III (deceased), DonaldW. Kufe, Robert C. Bast Jr., and Waun Ki Hong46 Palliative care and pain management 521Cardinale B. Smith47 Principles of psycho-oncology 531Jimmie C. Holland and TaliaW.Wiesel48 Principles of cancer rehabilitation medicine 537Michael D. Stubblefield, David C. Thomas, and Kristjan T. Ragnarsson49 Integrative oncology in cancer care 543Gabriel Lopez, Richard T. Lee, Alejandro Chaoul, M. Kay Garcia, and Lorenzo Cohen50 Health services research 549Michaela A. Dinan, Bradford R. Hirsch, and Amy AbernethyPart 7: INDIVIDUALIZED TREATMENT51 Personalized medicine in oncology drug development 561Nicholas C. Dracopoli, Iqbal Grewal, Chris H. Takimoto, and Peter F. LebowitzPart 8: CHEMOTHERAPY52 Preclinical and early clinical development of chemotherapeutic drugs, mechanism-based agents and biologics 573Axel-R. Hanauske and Daniel D. Von Hoff53 Tumor growth kinetics 589Elizabeth Comen, Teresa A. Gilewski, and Larry Norton54 Principles of dose, schedule, and combination therapy 601William N. Hait and Joseph P. Eder55 Pharmacology 613Manish R. Sharma and Mark J. Ratain56 Folate antagonists 625Peter D. Cole, Lisa Figueiredo, and Joseph R. Bertino57 Pyrimidine and purine antimetabolites 637Robert B. Diasio58 Alkylating agents and platinum antitumor compounds 649Zahid H. Siddik59 DNA topoisomerase targeting drugs 665AnishThomas, Susan Bates,WilliamD. Figg Sr, and Yves Pommier60 Agents targeting microtubules and mitotic processes 679Eric K. Rowinsky61 Endocrine therapy for hormone receptor-positive breast cancer 713Aman U. Buzdar, Shaheenah Dawood, Harold A. Harvey, and Virgil Craig Jordan62 Drug resistance and its clinical circumvention 733Jeffrey A.Moscow, KennethH. Cowan, and Branimir I. SikicPart 9: BIOLOGICAL AND GENE THERAPY63 Cytokines, interferons, and hematopoietic growth factors 743Suhendan Ekmekcioglu and Elizabeth A. Grimm64 Monoclonal serotherapy 757Robert C. Bast Jr., Michael R. Zalutsky, and Arthur E. Frankel65 Vaccines and immunostimulants 777Jeffery Schlom, James L. Gulley, and JamesW. Hodge66 Cell-based cancer immunotherapy 793Krina K. Patel, Judy S. Moyes, and Laurence J. Cooper67 Cancer immunotherapy 801Padmanee Sharma, Sumit K. Subudhi, Karl Peggs, Sangeeta Goswami, Jianjun Gao, Sergio Quezada, and James P. Allison68 Cancer gene therapy 817Haruko Tashiro and Malcolm Brenner69 Cancer nanotechnology 825Yanlan Liu, Danny Liu, Jinjun Shi, and Robert S. Langer70 Hematopoietic cell transplantation 831Roy Jones, Elizabeth Shpall, and Richard ChamplinPart 10: SPECIAL POPULATIONS71 Principles of pediatric oncology 845Teena Bhatla andWilliam L. Carroll72 Cancer and pregnancy 865Jennifer K. Litton73 Cancer and aging 875ArtiHurria,Hyman B. Muss, and Harvey J. Cohen74 Disparities in cancer care 883OtisW. Brawley75 Neoplasms in acquired immunodeficiency syndrome 891Jeremy S. Abramson and David T. Scadden76 Cancer survivorship: new challenge in cancer medicine 909Julia H. RowlandPart 11: DISEASE SITES77 Primary and metastatic neoplasms of the brain in adults 919Lisa M. DeAngelis78 Neoplasms of the eye 935Jasmine H. Francis, Amy C. Schefler, and David H. Abramson79 Neoplasms of the endocrine glands: pituitary neoplasms 949Chirag D. Gandhi, Margaret Pain, and Kalmon D. Post80 Neoplasms of the thyroid 959Steven I. Sherman, Maria E. Cabanillas, and Stephen Y. Lai81 Neoplasms of the adrenal cortex 967Tito Fojo82 Tumors of the diffuse neuroendocrine and gastroenteropancreatic system 971Evan Vosburgh83 Neoplasms of the head and neck 981Renata Ferrarotto, Merrill S. Kies, Adam S. Garden, and Michael E. Kupferman84 Cancer of the lung 1011Charles Lu, Daniel Morgensztern, Anne Chiang, Amir Onn, Boris Sepesi, Ara A. Vaporciyan, Joe Y. Chang, Ritsuko K. Komaki, Ignacio I. Wistuba, and Roy S. Herbst85 Malignant pleural mesothelioma 1037Daniel R. Gomez, Anne S. Tsao, Haining Yang, and Harvey I. Pass86 Thymomas and thymic tumors 1051Ronan J. Kelly and AlbertoM.Marchevsky87 Tumors of the heart and great vessels 1063Anthony F. Yu, Sai-Ching Jim Yeung, Carmen P. Escalante, Sarina van der Zee, A. P. Chahinian, and Valentin Fuster88 Primary germ cell tumors of the thorax 1069John D. Hainsworth and F. Anthony Greco89 Neoplasms of the esophagus 1075MaxW. Sung, Virginia R. Litle, Steven J. Chmura, Stephen G. Swisher, David C. Rice, Jaffer A. Ajani, Ritsuko K. Komaki, andMark K. Ferguson90 Carcinoma of the stomach 1091Carl Schmidt, Mariela Blum Murphy, James C. Yao, and Christopher H. Crane91 Primary neoplasms of the liver 1103Junichi Shindoh, KristofferW. Brudvik, and Jean-Nicolas Vauthey92 Gallbladder and bile duct cancer 1115Ahmed O. Kaseb, Marc Uemura,Melanie B. Thomas, and Steven A. Curley93 Neoplasms of the exocrine pancreas 1129Robert A.Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans, AnirbanMaitra, and Susan Tsai94 Neoplasms of the small intestine, vermiform appendix, and peritoneum, and carcinoma of the colon and rectum 1151Georgia M. Beasley, Zhifei Sun, Daniel P. Nussbaum, and Douglas S. Tyler95 Neoplasms of the anus 1177Bruce D. Minsky and Jose G. Guillem96 Renal cell carcinoma 1187Earle F. Burgess, Stephen B. Riggs, Brian I. Rini, and Derek Raghavan97 Urothelial cancer 1195Derek Raghavan, Richard Cote, Earle F. Burgess, Stephen B. Riggs, and Michael Haake98 Neoplasms of the prostate 1205Christopher J. Logothetis, Jeri Kim, JohnW. Davis, Brian F. Chapin, Deborah Kuban, Eleni Efstathiou, and Ana Aparicio99 Tumors of the penis and the urethra 1237James F. Holland, Raymond S. Lance, Donald F. Lynch Jr.100 Testis cancer 1243Christian Kollmannsberger, Craig R. Nichols, Siamak Daneshmand, Eric K. Hansen, Christopher L. Corless, Bruce J. Roth, and Lawrence Einhorn101 Neoplasms of the vulva and vagina 1269Summer B. Dewdney and Jacob Rotmensch102 Neoplasms of the cervix 1281Anuja Jhingran and Ana M. Rodriguez103 Endometrial cancer 1305Jamal Rahaman, Karen Lu, and Carmel J. Cohen104 Epithelial ovarian, fallopian tube, and peritoneal cancer 1317Jonathan S. Berek, Michael L. Friedlander, and Robert C. Bast Jr.105 Nonepithelial ovarian malignancies 1339Jonathan S. Berek, Michael L. Friedlander, and Robert C. Bast Jr.106 Molar pregnancy and gestational trophoblastic neoplasia 1353Donald P. Goldstein, Ross S. Berkowitz, and Neil S. Horowitz107 Gynecologic sarcomas 1361Jamal Rahaman and Carmel J. Cohen108 Neoplasms of the breast 1369Hope S. Rugo, Melanie Majure, Anthony Dragun, Meredith Buxton, and Laura Esserman109 Malignant melanoma 1441Justin M. Ko, Susan M. Swetter, Jonathan S. Zager, Vernon K. Sondak, Scott E.Woodman, and Kim A. Margolin110 Other skin cancers 1461William G. Stebbins, Eric A. Millican, and Victor A. Neel111 Bone tumors 1475Timothy A. Damron112 Soft tissue sarcomas 1499Robert G. Maki, Chandrajit P. Raut, and Brian O'Sullivan113 The myelodysplastic syndrome 1529Lewis R. Silverman114 Acute myeloid leukemia in adults: mast cell leukemia and other mast cell neoplasms 1545Richard M. Stone and Charles A. Schiffer115 Chronic myeloid leukemia 1571Jorge Cortes, Richard T. Silver, and Hagop M. Kantarjian116 Acute lymphoblastic leukemia 1581Nitin Jain, Stefan Faderl, Hagop M. Kantarjian, and Susan O'Brien117 Chronic lymphocytic leukemia 1595Kanti R. Rai and Jacqueline C. Barrientos118 Hodgkin lymphoma 1605Carol S. Portlock, Anita Kumar, and James Armitage119 Non-Hodgkin's lymphoma 1615Arnold S. Freedman and Ann S. LaCasce120 Mycosis fungoides and Sézary syndrome 1629Richard T. Hoppe, Youn H. Kim, and Ranjana H. Advani121 Plasma cell tumors 1635Noopur Raje, Teru Hideshima, Andrew J. Yee, and Kenneth C. Anderson122 Myeloproliferative neoplasms: essential thrombocythemia, primary myelofibrosis, and polycythemia vera 1659Ayalew TefferiPart 12: MANAGEMENT OF CANCER COMPLICATIONS123 Neoplasms of unknown primary site 1673John D. Hainsworth and F. Anthony Greco124 Anorexia and cachexia 1685Takao Ohnuma125 Antiemetic therapy 1693Patrick M. Forde and David S. Ettinger126 Neurologic complications of cancer 1701Lisa M. DeAngelis127 Dermatologic complications of cancer chemotherapy 1717Anisha B. Patel and Madeleine M. Duvic128 Skeletal complications 1727Michael A. Via, Ilya Iofin, and Jeffrey I. Mechanick129 Hematologic complications and blood bank support 1737Richard M. Kaufman and Kenneth C. Anderson130 Coagulopathic complications of cancer patients 1745Maria T. De Sancho and Jacob H. Rand131 Urologic complications 1755Rachel A. Sanford, Ala Abudayyeh, Christopher J. Logothetis, andNizar M. Tannir132 Cardiac complications 1763Michael S. Ewer, Steven M. Ewer, andThomas Suter133 Respiratory complications 1781Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Horiana B. Grosu, Rodolfo C. Morice, Lara Bashoura, Scott E. Evans, Roberto Adachi, Michael Kroll, Saadia A. Faiz, Diwakar D. Balachandran, Selvaraj E. Pravinkumar, and Burton F. Dickey134 Gastrointestinal and hepatic complications in cancer patients 1807Robert S. Bresalier, H. Franklin Herlong, and Boris Blechacz135 Oral complications of cancer and their treatment 1821Stephen T. Sonis and Anna Yuan136 Gonadal complications 1833Vignesh Narayanan and Catherine E. Klein137 Sexual dysfunction 1843Leslie R. Schover138 Endocrine complications and paraneoplastic syndromes 1849Sai-Ching Jim Yeung and Robert F. Gagel139 Infections in patients with cancer 1865Lior Nesher and Kenneth V. I. Rolston140 Oncologic emergencies 1879Sai-Ching Jim Yeung and Carmen P. EscalantePart 13: THE FUTURE OF ONCOLOGY141 A vision for twenty-first century healthcare 1901Leroy Hood, Kristin Brogaard, and Nathan D. PriceIndex 1911