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Neurodegeneration and Alzheimer's Disease

Neurodegeneration and Alzheimer's Disease

Publisher Blackwell Science
Year 01/07/2019
Edition First
Pages 544
Version hardback
Readership level Professional and scholarly
Language English
ISBN 9781119356783
Categories Clinical & internal medicine, Other technologies & applied sciences
$164.16 (with VAT)
617.00 PLN / €137.90 / £122.86
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Book description

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer's and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer's disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism - and associated nutritional and lifestyle variables - may factor into such disorders' prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer's disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer's disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer's and Parkinson's disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer's disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Neurodegeneration and Alzheimer's Disease

Table of contents

List of Contributors xv

1 Current Understanding of Alzheimer's Disease and Other Neurodegenerative Diseases, and the Potential Role of Diet and Lifestyle in Reducing the Risks of Alzheimer's Disease and Cognitive Decline 1
Charles S. Brennan, Margaret A. Brennan, W.M.A.D. Binosha Fernando and Ralph N. Martins

References 7

2 Alzheimer's Disease and Other Neurodegenerative Diseases 9
Stephanie J. Fuller, Hamid R. Sohrabi, Kathryn G. Goozee, Anoop Sankaranarayanan and Ralph N. Martins

2.1 Introduction 9

2.2 Alzheimer's Disease 9

2.2.1 Pathology 9

2.2.2 Symptoms 10

2.2.3 Incidence 11

2.2.4 Onset and Risk Factors 12

2.2.5 Treatment 12

2.2.6 Potential for AD Prevention 13

2.3 Frontotemporal Lobe Dementia 13

2.3.1 Neuropathology and Causes 14

2.3.2 Treatment 15

2.3.3 Diagnosis and Clinical Overlap with Other Diseases 15

2.4 Vascular Dementia 16

2.4.1 Symptoms and Diagnosis 16

2.4.2 Causes and Risk Factors 16

2.4.3 Prevention and Treatment 17

2.4.4 Dementia with Lewy Bodies 18

2.4.5 Causes 18

2.4.6 Symptoms 18

2.4.7 Diagnosis of DLB 18 Clinical Approach to Dementias 19

2.5 Parkinson's Disease 19

2.5.1 Onset 22

2.5.2 Causes and Risk Factors 22

2.5.3 Incidence 22

2.5.4 Pathology 22

2.5.5 Treatment 23

2.6 Huntington's Disease 24

2.6.1 Genetics of the Disease 24

2.6.2 Incidence and Prevalence 25

2.6.3 Pathology 25

2.6.4 Treatment 26

2.7 Motor Neuron Diseases 27

2.7.1 Amyotrophic Lateral Sclerosis 27

2.7.2 Spinal Muscular Atrophy 27

2.7.3 Hereditary Spastic Paraplegia 27

2.7.4 Onset of MND and Differential Diagnosis 28

2.7.5 Incidence, Causes, and Risk Factors 28

2.7.6 Pathology 29

2.7.7 Treatment 30

2.8 Prion Diseases 30

2.8.1 Causes 31

2.8.2 Symptoms and Diagnosis 31

2.8.3 Treatment 32

2.8.4 Differential Diagnosis of the Various Types of Dementia 32

2.8.5 DLB Treatment 33

2.9 Summary 33

References 34

3 Current and Developing Methods for Diagnosing Alzheimer's Disease 43
Stephanie J. Fuller, Nicholas Carrigan, Hamid R. Sohrabi and Ralph N. Martins

3.1 Introduction 43

3.2 Classical Post-Mortem Diagnosis 43

3.2.1 Plaques 44

3.2.2 Neurofibrillary Tangles (NFT) 44

3.2.3 Cerebral Amyloid Angiopathy (CAA) 44

3.2.4 Glial Responses 45

3.2.5 Brain Shrinkage 45

3.2.6 Loss of Synapses and Neurons 45

3.3 Clinical Diagnosis 45

3.3.1 Initial Assessment/Screening Tools 47 Mini-Mental State Examination (MMSE) 47 Montreal Cognitive Assessment (MoCA) 47 Clinical Dementia Rating (CDR)

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