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Poisonous Plants and Phytochemicals in Drug Discovery

Poisonous Plants and Phytochemicals in Drug Discovery

Authors
Publisher Blackwell Science
Year 01/02/2021
Edition First
Pages 432
Version hardback
Readership level Professional and scholarly
Language English
ISBN 9781119650232
Categories Pharmacology, Medical toxicology, Chemistry, Biology, life sciences, Biochemistry, Toxicology (non-medical)
$195.12 (with VAT)
863.04 PLN / €185.88 / £157.50
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Book description

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Poisonous Plants and Phytochemicals in Drug Discovery

Table of contents

Chapter 1: HISTORICAL USE OF TOXIC PLANTS


1.1 Introduction to toxic plants


1.2 Plant sources of poisons and their active principle


1.3 Poisonous plants as sources of traditional and modern medicines


1.4 Toxic plants and justice


1.4.1 Toxic plants in capital punishment


1.4.2 Trial by ordeal


1.5 Toxic plants in poisoned weapons


1.5.1 Arrow poisons


1.6 Plant fishing poisons/ piscicides/ ichthyotoxins


1.7 Poisonous plants as food


1.8 Poisonous plants as biopesticides


1.9 Toxic psychoactive plants for recreational and religious purposes


1.10 Poisonous plants in warfare & bioterrorism


1.11 Poisonous plants as carcinogens and teratogens


1.12 Conclusion


Chapter 2: CLASSIFICATION OF PHYTOTOXINS AND THEIR MECHANISMS OF ACTION


2.1 Introduction 2


2.1.1 Endophytic phytotoxins 3


2.1.2 Secondary metabolites 4


2.2 Possible categorization 4


2.2.1 Biological characteristics 4


2.2.2 Chemical characteristics 5


2.3 Currently available classification tools 7


2.4 Role of phytotoxin classification 7


2.4.1 Drug discovery 8


2.4.2 Environmental monitoring 8


2.4.3 Phytotoxins, aquatic life and Water quality 8


2.4.4 Air contamination 9


2.4.5 Food contamination 9


2.4.6 Security and safety services 10


2.4.7 Agricultural 10


2.5 Brief mechanisms of action 10


2.6 Conclusion 10


Reference 11


CHAPTER 3: POISONOUS PLANTS AS SOURCES OF ANTI-CANCER AND OTHER DRUGS


3.1 Introduction 2


3.2 Poisonous plants in cancer treatment and others disease 3


3.3 Poisonous Plant based anti-cancer drugs on the market 35


3.4 Poisonous Plant based drugs on the market against other diseases 36


3.5 Conclusion 38


References 38


Chapter 4: DRUGS IN CLINICAL PRACTICE FROM TOXIC PLANTS AND PHYTOCHEMICALS


4.1 Introduction 2


4.2 Drugs in clinical practice from toxic plants 3


4.3 Drugs Acting on the Central Nervous System 4


4.4 Physostigmine and Other Acetylcholinesterase Inhibitors 8


4.5 Antitumor Agents 9


4.6 Other Drugs 12


4.7 Nicotine and the neonicotinoids 14


References 15


Chapter 5: TOXICOLOGY AND HEALTH BENEFITS OF PLANT ALKALOIDS


5.1 Introduction 1


5.2 Pharmacological Properties of alkaloids 4


5.3 Toxicological Properties of Alkaloids 8


5.5 Acute and Chronic Toxicities 9


5.5.1 Genotoxicity and Tumourigenicity 10


5.5.2 Lung, neurotoxicity and teratogenicity 11


5.6 Factors that Influence the Toxicological Profile of Alkaloids 13


5.7 Conclusion 14


References 14


Chapter 6: CHEMICAL AND PHARMACOLOGICAL MECHANISMS OF PLANT-DERIVED NEUROTOXINS


6.1 Introducti

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