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This book aims to serve as the complete reference on Bordetella pertussis, which has made a resurgence in recent years. Included in its scope are the following topics:   ·         Discussion of all aspects of pertussis resurgence and the discovery of pertussis in adults ·         Pathology and clinical manifestations ·         The development of new diagnostic methods and treatments ·         Concern about reactogenicity of DTwP vaccines ·         The development, testing, and licensure of DTaP and Tdap vaccines ·         The demonstration of why DTaP vaccines fail ·         Progress in the understanding of the epidemiology of B. pertussis infection ·         Progress in the understanding of the cause of death and its prevention in infants   Whooping Cough Due to Bordetella pertussis and Other Bordetella Subspecies aims to fill the gap in current information, and detail all recent advances in the understanding and treatment of this serious illness.

Whooping Cough Due to Bordetella pertussis and other Bordetella Subspecies

INTRODUCTION HISTORY PHYLOGENETIC RELATIONSHIPS BETWEEN BORDETELLA SUBSPECIEIS VIRULENCE DETERMINANTS AND MOLECULAR PATHOGENESIS             Animal Models and humans             Virulence Determinants                         Filamentous hemagglutinin                         Agglutinogens                         Fimbriae                         Pertactin and other autotransporters                         Adenylate cyclase                         Dermonecrotic toxin                         Lipopolysaccharides                         Type III secretion system                         Tracheal cytotoxin                         Pertussis toxin Other: All other proteins and polysaccharides (capsule) will also be presented as possible virulence determinants. PATHOLOGY             B. pertussis Infection             B. bronchiseptica Infection PATHOGENESIS AND IMMUNITY CLINICAL MANIFESTATIONS             B. pertussis                         Classic illness                           Mild illness and asymptomatic infection                         Infants                         Adults             B. parapertussis             B. bronchiseptica             B. holmesii DIAGNOSIS             Differential Diagnosis of Bordetella Infections             Specific Diagnosis of B. pertussis Infections             Culture of B. pertussis             Detection of B. pertussis by PCR             Serologic diagnosis of B. pertussis Infection TREATMENT VACCINATION AND PREVENTION             B. pertussis Vaccines                         Whole-cell DTP vaccines (i)             Reactogenicity (ii)            Vaccine efficacy Acellular pertussis component DTP vaccines (i)             Reactogenicity (ii)            Vaccine efficacy Possible new vaccines EPIDEMIOLOGY: IMPLICATIONS FOR THE CONTROL OF HUMAN INFECTIONS             B. pertussis Epidemiology                         Observed (reported pertussis) (i)             Incidence (ii)            Mortality (iii)           Sex and race (iv)          Season and geographic areas B. pertussis infection (i)         Percentage of cough illnesses due to B. pertussis in adolescents and adults (ii)         Rate of B. pertussis infections (iii)           Rate of cough illnesses due to B. pertussis infections B. parapertussis Epidemiology             Incidence and mortality             Sex, race, season, and geographic areas             Interrelationship between B. parapertussis and B. pertussis infections B. bronchiseptica Epidemiology B. holmesii Epidemiology LONG-TERM GOALS OF PERTUSSIS PREVENTION             Eradication of B. pertussis Circulation             Lesser Goals FUTURE RESEARCH             Pathogenesis of disease             Better Vaccines             More Complete Epidemiologic Study REFERENCES