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Inducing Targeted Protein Degradation: From Chemical Biology to Drug Discovery and Clinical Applications

Inducing Targeted Protein Degradation: From Chemical Biology to Drug Discovery and Clinical Applications

Publisher Wiley-Vch
Year 02/01/2023
Pages 384
Version hardback
Language English
ISBN 9783527350131
Categories
$163.45 (with VAT)
726.60 PLN / €155.78 / £135.23
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Book description

The guide to induced protein degradation for drug developers in academia and industry surveys established and novel approaches in the field, with an eye on expanding the range of druggable targets.

Inducing Targeted Protein Degradation: From Chemical Biology to Drug Discovery and Clinical Applications

Table of contents

Targeted Protein Degradation - The Story So Far Cellular Principles of Targeted Protein Degradation E3 Ubiquitin Ligases as Molecular Machines and Platforms for Drug DevelopmentA Structural and Biophysical Perspective of Degrader Activity through Ternary Complex Formation Computational Modeling of PROTAC Ternary Complexes and Linker Design Molecular Glue Degraders: From Serendipity to Hunting and DesignTargeted Protein Degradation as a Therapeutic Strategy in Neurodegenerative Diseases Insights and Future Perspectives of Covalent Protein Degraders Extending the Degradation Toolkit - mRNA targeting as Alternative Means to Affect Protein LevelsThe Future of Heterobifunctional Compounds: PROTACs and Beyond Destruction with a Purpose: Targeted Protein Degradation in Drug DiscoveryTaming the Beast: How to Optimize DMPK-PD Properties of Oral Degraders PROTAC® Protein Degraders: Bridging the Divide from Chemical Biology Tools to Clinical Candidates

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