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This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I Conference in 2006. Written by experts in the field, it addresses a critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that these findings will help readers to prevent and treat the long-term side-effects of irradiation.

CURED I - LENT Late Effects of Cancer Treatment on Normal Tissues

Radiation (and Medical) Biosurveillance: Screening Survivors for Late Effects of Therapy.- Radiation Biodefense: Medical Countermeasures to Radiation Injury: Science and Service in the Public Interest. A Tribute to Robert Kallman.- Radiation Biopathology: Ionizing Radiation and the Endothelium.- Radiation Biomarkers: Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.- Radiation Biomechanisms: Volume Effects in Radiation Damage to Rat Lung.- Radiation Bioimaging: The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury.- Radiation Biophysiology: Screening for Cardiovascular Disease in Survivors of Thoracic Radiation.- Radiation Biointervention: Hypoxia Mediated Chronic Normal Tissue Injury: A New Paradigm and Potential. Strategies for Intervention.- Radiation Bioprevention: Prevention and Treatment of Radiation Injuries: The Role of the Renin-Angiotensin System.- Radiation Bioepidemiology: Second Malignancies as a Consequence of Radiation Therapy.- Radiation Bioinformatics: Using Quality of Life Information to Rationally Incorporate Normal Tissue Effects into Treatment Plan Evaluation and Scoring.- Radiation Bioscoring: Cancer-Related Fatigue as a Late Effect: Severity in Relation to Diagnosis, Therapy, and Related Symptoms.- Radiation Biotoxicity Taxonomy: A Normal Tissue TNM Toxicity Taxonomy: Scoring the Adverse Effects of Cancer Treatment.- Radiation Biocontinuum: Follow-Up Care For Cancer Survivors: Needs, Issues, and Strategies.