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Steering clear of quantum mechanics and product operators, "Pocket Guide to Biomolecular NMR" uses intuitive, concrete analogies to explain the theory required to understand NMR studies on the structure and dynamics of biological macromolecules. For example, instead of explaining nuclear spin with angular momentum equations or Hamiltonians, the books describes nuclei as "bells" in a choir, ringing at specific frequencies depending on the atom type and their surrounding electromagnetic environment.This simple bell analogy, which is employed throughout the book, has never been used to explain NMR and makes it surprisingly easy to learn complex, bewildering NMR concepts, such as dipole-dipole coupling and CPMG pulse sequences. Other topics covered include the basics of multi-dimensional NMR, relaxation theory, and Model Free analysis. The small size and fast pace of "Pocket Guide to Biomolecular NMR" makes the book a perfect companion to traditional biophysics and biochemistry textbooks, but the book's unique perspective will provide even seasoned spectroscopists with new insights and handy "thought" short-cuts.

Pocket Guide to Biomolecular NMR

1Atomic Bells and Frequency Finders1.1Chemical Choirs1.2Essentials of Electromagnetism 1.3Electromagnetic Microsensors1.4Frequency FindersMathematical Sidebar 1.1: Fourier Transform1.5 Basics of one-dimensional NMRMathematical Sidebar 1.2 Converting Hz to PPMReferences2Bonded Bells and Two-Dimensional Spectra 2.1Introduction to Coupling2.2Bonded Bells: J-CouplingMathematical Sidebar 2.1: Karplus Equation2.3NMR Maps: Two-Dimensional SpectraMathematical Sidebar 2.2 Why 12C and 14N atoms are so shy? 2.4The 1H-15N HSQC: Our Bread and Butter2.5Hidden Notes: Creating Two-Dimensional SpectraReferences3Neighboring Bells and Structure Bundles3.1Bumping Bells: Dipole-Dipole CouplingMathematical Sidebar 3.1: Dipole-dipole Coupling3.2Atomic Meter Stick: the NOE 3.3 Into "Three-D" 3.4Adult "Connect-the-Dots:" HNCA 3.5Putting the Pieces Together: A Quick Review3.6Wet Noodles and Proteins Bundles: Building a Three-Dimensional StructureReferences4Relaxation Theory Part One: Silencing of the Bells 4.1Nothing Rings Forever: Two Paths to Relax4.2Relaxation: Ticket to the Protein PromMathematical Sidebar 4.1: Boltzmann Distribution4.3Oh-My, How Your Field Fluctuates4.4Blowing Off Steam and Returning to Equilibrium: T1Mathematical Sidebar 4.2: T1 Relaxation4.5Loosing Lock-Step : Coherence and T2Mathematical Sidebar 4.3: T2 Relaxation and Spin EchoReferences5Relaxation Theory Part Two: Moving Atoms and Changing Notes 5.1Keeping the Terms Straight5.2NMR Dynamics in a Nutshell: The Rules of Exchange5.3Two States, One Peak: Atoms in the Fast Lane of Exchange5.4Two States, Two Peaks: Atoms in the Slow Lane of Exchange5.5Two States, One Strange Peak: Atoms in Intermediate Exchange5.6Tumbling Together: Rotational Correlation Time ( c)5.7SummaryReferences6Protein Dynamics6.1Dynamics Analysis by NMR: Multli-Channel Metronomes, Not a GPS6.2Elegant Simplicity: Lipari and Szabo Throw Out the Models 6.3Wagging Tails and Wiggling Bottoms: Local versus Global Motion6.4Measuring Fast Motion: Model Free AnalysisMathematical Sidebar 6.1: Correlation Functions and Model Free6.5Changing Directions on the Track: Refocusing Pulses6.6Measuring Intermediate Motion: CPMG Relaxation Dispersion Analysis6.7Measuring Slow Motion: Z-Exchange Spectroscopy6.8 Measuring Motion SummaryReferences