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This book illustrates the importance and significance of Quorum sensing (QS), it's critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. 

Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.

Implication of Quorum Sensing System in Biofilm Formation and Virulence

Chapter 1_Introduction to Microbial Quorum Sensing.- Chapter 1.1. Introduction to microbial quorum sensing molecules and biofilm formation.- Chapter 1.2. Intra and inter-species communications in microbes: Living with complex and sociable neighbours.- Chapter 1.3. Relationship between Quorum Sensing Systems and Persister Cells.- Chapter 1.4. Microbial Social Interactions in Biofilm.- Chapter 2. Functional Aspects of Quorum Sensing in Microbes.- Chapter 2.1. Quorum sensing and swarming migration in bacteria.- Chapter 2.2. Quorum Sensing and Paradigms of microbial Pathogenic relationships. - Chapter 2.3. Cellular signalling in bacterial biofilms.- Chapter 2.4. Quorum sensing in bacterial pathogenesis and virulence.- Chapter 2.5. Quorum sensing in Bacteria-Plant interactions.- Chapter 2.6. Microbes living together: Exploiting the art for making biosurfactants and biofilms.- Chapter 2.7.   Quorum sensing and their role in regulation of Antibiotics Synthesis - Chapter 3. Quorum Sensing regulated behaviors in Fungi.- Chapter 3.1. Role of Quorum Sensing on Morphogenesis and Biofilm formation in fungi.- Chapter 3.2. Perspective of Quorum sensing mechanism in Candida albicans.- Chapter 4. Quorum Sensing regulated behaviours in Gram-negative bacteria.- Chapter 4.1. Vibrio fischeri synchronizes bioluminescence in marine invertebrates via Quorum sensing mechanism.- Chapter 4.2. Quorum sensing system regulates virulence and pathogenicity genes in Vibrio harveyi.- Chapter 4.3. Simplifying the complexity of quorum sensing signalling of the gut Enterobacteria: Escherichia coli and Salmonella enterica.- Chapter 4.4. Quorum-sensing mechanism in Rhizobium sp:  Revealing the complexity in a dialogue.- Chapter 4.5. Quorum Sensing and Its role in Agrobacterium Mediated Gene Transfer.- Chapter 4.6. Quorum sensing and Biofilm formation in Helicobacter pylori.- Chapter 4.7. Quorum sensing and biofilm disassembly process in Pseudomonas aeruginosa, Staphylococcus aureus and Xanthomonas campestris: A comparative study.- Chapter 5. QS-regulated behaviours in Gram- Positive bacteria.- Chapter 5.1. Quorum sensing mechanisms in Gram Positive Bacteria.- Chapter 5.2. Novel insights on Bacillus Quorum sensing mechanism: Its role in competence, virulence, sporulation and biofilm formation.- Chapter 5.3. Quorum sensing in Mycobacterium tuberculosis: Its role in virulence and pathogenesis.- Chapter 5.4. Quorum sensing in Streptococcus pyogenes and their role in establishment of disease.