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Toxicology

Toxicology

Autorzy
Wydawnictwo Elsevier Science Publishers
Data wydania 01/10/1999
Wydanie Pierwsze
Liczba stron 1330
Forma publikacji inne
Język angielski
ISBN 9780080543116
Kategorie Medycyna: zagadnienia ogólne
licencja wieczysta
Produkt dostępny on-line
Typ przesyłki: wysyłka kodu na adres e-mail
E-Mail
zamówienie z obowiązkiem zapłaty
Do schowka

Opis książki

Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.Key Features* Comprehensive text, covering all aspects of the field of toxicology* Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects* Identifies the various classes of chemical compounds responsible for the toxic effects* Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention* Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables

Toxicology

Spis treści


  • Cover

  • Copyright Page

  • Contents

  • Contributors

  • Preface

  • Introduction

  • Paracelsus to Parascience: The Dose/Trace Makes the Poison

  • Even Rachel Carson Was Made of Chemicals: Natural versus Synthetic Chemicals

  • Errors of Omission: Toxicity of Insufficient Micronutrients

  • Damage by Distraction: Regulating Low Hypothetical Risks

  • PART I: FUNDAMENTALS

  • Chapter 1. History of Toxicology

  • Toxicology?The Science of Poison

  • Early Fundamental Developments

  • From Alchemy to the Development of a Pure Science

  • Academic Qualification and the Practical Application of Toxicological Knowledge at the Beginning of

  • Chemistry and the Chemical Industry in the Nineteenth Century

  • Substance Effects?Uses and Limits

  • The Scope of Toxicology in Historic Terms

  • Chapter 2. Biostatistics in Toxicology

  • Principles

  • Acute Toxicity

  • Chronic Toxicity

  • Reproductive Toxicology

  • Mutagenicity Studies

  • Carcinogenicity Studies

  • Biostatistics in Regulatory Toxicology

  • Chapter 3. Principles of Toxicokinetics

  • Introductory Remarks

  • Principal Kinetic Parameters

  • Kinetic Models

  • Kinetic Principles of Drug Dosing

  • Nonlinear Kinetics

  • Stereoselective Kinetics

  • Variability of Kinetic Parameters

  • Species Differences in Kinetics

  • Chapter 4. Xenobiotic Metabolism

  • Introduction

  • Classification of Xenobiotic- Metabolizing Enzymes

  • Characterization of Individual Xeno

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