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Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development

Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development

Autorzy
Wydawnictwo Taylor & Francis Inc
Data wydania 1999
Liczba stron 696
Forma publikacji książka w twardej oprawie
Poziom zaawansowania Dla profesjonalistów, specjalistów i badaczy naukowych
Język angielski
ISBN 9780824719951
Kategorie Przemysł farmaceutyczny
1 203.30 PLN (z VAT)
$270.68 / €257.99 / £223.96 /
Produkt na zamówienie
Dostawa 5-6 tygodni
Ilość
Do schowka

Opis książki

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.
Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!
Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems
discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology

analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces

covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions

examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles

describes vaginal, nasal, buccal, ocular, and transdermal drug delivery

reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts

explores issues of product development, clinical testing, and production

and more!
Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologist

Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development

Spis treści

Fundamentals of Bioadhesion

Definitions, Mechanisms, and Theories of Bioadhesion

Donald E. Chickering III and Edith Mathiowitz

The Role of Water Movement and Polymer Hydration in Mucoadhesion

John D. Smart

A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels

Carla Marcella Caramella, Silvia Rossi, and Maria Cristina Bonferoni

Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina

Udo Schumacher and Dietlind Schumacher

Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins

Barry James Campbell

Methods of Evaluating Bioadhesive Interactions

Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres

Donald E. Chickering III, Camilla A. Santos, and Edith Mathiowitz

Novel Magnetic Technique to Measure Bioadhesion

Benjamin A. Hertzog and Edith Mathiowitz

Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems

Michael Horstmann, Walter Muller, and Bodo Asmussen

Force Microscopy of Cells to Measure Bioadhesion

E. zur Muhlen, P. Koschinski, S. Gehring, Robert Ros, Louis Tiefenhauer, Eleonore Haltner, Claus-Michael Lehr, Uwe Hartmann, Falk Schwesinger, and A. Pluckthun

Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems

James Schneider and Matthew Tirrell

A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction

Cheng Zhu, James W. Piper, and Robert A. Swerlick

Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems

Multifunctional Polymers for the Peroral Delivery of Peptide Drugs

Henrik L. Luessen, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, Bas J. de Leeuw, Gerrit Borchard, and Claus-Michael Lehr

Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia

A. F. Kotze, Henrik L. Luessen,

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