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Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research. Interest in nitric oxide biology has greatly intensified over the past decade in concert with our increasing appreciation of its many roles in the cardiovascular systems. In Nitric Oxide and the Cardiovascular System, world leaders in the field comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in cardiovascular health and disease. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine.
With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Nitric Oxide and the Cardiovascular System

Part I. Biology of Nitric Oxide. The Biological Chemistry of Nitric Oxide, Joseph Loscalzo. Cell and Molecular Biology of Nitric Oxide Synthases, Olivier Feron and Thomas Michel. Cellular Signal Transduction and Nitric Oxide, Stanley Heydrick. Regulation of Gene Expression by Nitric Oxide, Ami A. Deora and Harry M. Lander. Cytotoxicity, Apoptosis, and Nitric Oxide, Stefanie Dimmeler and Andreas M. Zeiher. Nitric Oxide and Ion Channels, Victoria M. Bolotina. Role of Nitric Oxide in Vasomotor Regulation, Richard A. Cohen. Nitric Oxide and Platelet-Mediated Hemostasis, Elisabeth M. Battinelli and Joseph Loscalzo. Nitric Oxide Modulates Leukocyte-Endothelial Cell Adhesion, Wolfgang Cerwinka and D. Neil Granger. Nitric Oxide and Cardiomyocyte Function, Jean-Luc Balligand and Paul J. Cannon. The Fibroblast and Nitric Oxide, Peter Brecher. Nitric Oxide in Cardiac Electrophysiology, Lü Fei and Douglas P. Zipes. Part II. Cardiovascular Pathophysiology of Nitric Oxide. Nitric Oxide and Endothelial Dysfunction, Gerard A. Dillon and Joseph A. Vita. Nitric Oxide and Hypertension, M. Audrey Rudd, María R. Trolliet, and Joseph Loscalzo. Nitric Oxide and Pulmonary Hypertension, John J. Leopore and Kenneth D. Bloch. Nitric Oxide in Atherosclerosis, Robert T. Eberhardt and Joseph Loscalzo. Thrombotic Disorders and Nitric Oxide Insufficiency, Jane E. Freedman and Joseph Loscalzo. Myocardial Nitric Oxide in Heart Failure, Douglas B. Sawyer and Wilson S. Colucci. Shock States and Nitric Oxide, Hartmut Ruetten and Christoph Thiemermann. Stroke and Nitric Oxide, Nancy E. Stagliano and Paul L. Huang. The Role of Nitric Oxide in Ischemia-Reperfusion, Allan M. Lefer and Reid Hayward. Part III. Nitric Oxide in Cardiovascular Therapeutics. Nitrovasodilators, John D. Horowitz. S-Nitrosothiols, Jane A. Leopold and Joseph Loscalzo. Diazeniumdiolates (Formerly NONOates) in Cardiovascular Research and Potential Clinical Applications, Joseph E. Saavedra, Anthony L. Fitzhugh, and Larry K. Keefer.Inhaled Nitric Oxide Therapy for Acute Respiratory Failure, William Hurford and Warren M. Zapol. Antioxidants and Endothelium-Derived Nitric Oxide Action, Annong Huang and John F. Keaney, Jr. Coating Arterial and Blood-Contacting Surfaces with NO--Donating Compounds, John D. Folts and Joseph Loscalzo. Gene Therapy and Nitric Oxide, Heiko E. von der Leyen. Nitric Oxide and Tissue Preservation in Transplantation, David J. Pinsky and David M. Stern. L-Arginine: Its Role in Cardiovascular Therapy, Andrew J. Maxwell and John P. Cooke. Index.