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The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD.* A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms* Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context* Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage* Review of the development of the evidence-base for transfusion medicine* Content on the clinical practice for transfusion and alternatives to transfusion

Practical Transfusion Medicine

List of Contributors ixPreface xv1 Introduction: Two Centuries of Progress in Transfusion Medicine 1Walter H. (Sunny) Dzik and Michael F. MurphyPart I Basic Principles of Immunohaematology 112 Essential Immunology for Transfusion Medicine 11Jaap Jan Zwaginga and S. Marieke van Ham3 Human Blood Group Systems 20Geoff Daniels4 Human Leucocyte Antigens 29Cristina V. Navarrete and Colin J. Brown5 Platelet and Neutrophil Antigens 43Brian R. Curtis6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58Mark H. Yazer and Meghan DelaneyPart II Complications of Transfusions 697 Investigation of Acute Transfusion Reactions 69Kathryn E. Webert and Nancy M. Heddle8 Haemolytic Transfusion Reactions 81Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman9 Febrile and Allergic Transfusion Reactions 97Mark K. Fung and Nancy M. Heddle10 Lung Injury and Pulmonary Oedema After Transfusion 108Steven H. Kleinman and Daryl J. Kor11 Purported Adverse Effects of 'Old Blood' 118Lirong Qu and Darrell J. Triulzi12 Transfusion?]Induced Immunomodulation 125Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg13 Transfusion?]Associated Graft?]Versus?]Host Disease and Microchimerism 136Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer14 Posttransfusion Purpura 147Michael F. Murphy15 Transfusion?]Transmitted Infections 153Roger Y. Dodd and Susan L. Stramer16 Bacterial Contamination 168Sandra Ramírez?]Arcos and Mindy Goldman17 Emerging Infections and Transfusion Safety 176Roger Y. DoddPart III Practice in Blood Centres and Hospitals 18418 Regulatory Aspects of Blood Transfusion 184William G. Murphy, Louis M. Katz and Peter Flanagan19 The Role of Haemovigilance in Transfusion Safety 193Katharine A. Downes and Barbee I. Whitaker20 Donors and Blood Collection 203Marc Germain, Ellen McSweeney and William G. Murphy21 Blood Donation Testing and the Safety of the Blood Supply 215Mindy Goldman22 Production and Storage of Blood Components 222Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo23 Blood Transfusion in Hospitals 233Erica M. Wood, Mark H. Yazer and Michael F. Murphy24 Blood Transfusion in a Global Context 254David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan DelaneyPart IV Clinical Transfusion Practice 26425 Inherited and Acquired Coagulation Disorders 264Irina Chibisov and Franklin Bontempo26 Massive Blood Loss 279John R. Hess27 Blood Management in Acute Haemorrhage and Critical Care 287Gavin J. Murphy, Nicola Curry, Nishith N. Patel and Timothy S. Walsh28 Point?]of?]Care Testing in Transfusion Medicine 302Matthew D. Neal and Louis H. Alarcon29 Haematological Disease 312Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy30 Blood Transfusion in the Management of Patients with Haemoglobinopathies 330Enrico M. Novelli31 Heparin?]Induced Thrombocytopenia 341Andreas Greinacher and Theodore E. Warkentin32 Immunodeficiency and Immunoglobulin Therapy 357Siraj A. Misbah33 Transfusing Neonates and Infants 371Ronald G. StraussPart V Patient Blood Management 38334 Development of a Patient Blood Management Programme 383Jonathan H. Waters35 Perioperative Patient Blood Management 393Martin Rooms, Ravishankar Rao Baikady and Toby Richards36 Restrictive Transfusion Practice and How to Implement It 405Lawrence Tim Goodnough and Neil Shah37 Using Data to Support Patient Blood Management 416Steven M. Frank and Jack O. WaseyPart VI Cellular and Tissue Therapy and Organ Transplantation 42938 Regulation and Accreditation in Cellular Therapy 429Zbigniew (Ziggy) M. Szczepiorkowski and Daniel Hollyman39 Stem Cell Collection and Therapeutic Apheresis 442Khaled El?]Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski40 Haemopoietic Stem Cell Processing and Storage 455Hira Mian, Ronan Foley and Pamela O'Hoski41 Haematopoietic Stem Cell Transplantation 466Robert D. Danby, Rachel Protheroe and David J. Roberts42 Cord Blood Transplantation 477Rachael Hough and Robert D. Danby43 Recent Advances in Clinical Cellular Immunotherapy 490Mark W. Lowdell and Emma Morris44 Tissue Banking 500Akila Chandrasekar, Paul Rooney and John N. KearneyPart VII Development of the Evidence Base for Transfusion 50845 Observational and Interventional Trials in Transfusion Medicine 508Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert46 Getting the Most Out of the Evidence for Transfusion Medicine 520Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Sally Hopewell47 A Primer on Biostatistics 533Andrew W. Shih and Nancy M. Heddle48 A Primer on Health Economics 549Seema Kacker and Aaron A. R. Tobian49 Scanning the Future of Transfusion Medicine 560Jay E. Menitove, Paul M. Ness and Edward L. SnyderIndex 572