Książki

Die brandneue aktualisierte Ausgabe des wohl umfassendsten Referenzwerks zu Erkrankungen der Bauchspeicheldrüse präsentiert im Detail die neuesten Erkenntnisse zu Genetik und molekularbiologischen Hindergründen im Hinblick auf Anatomie, Physiologie, Pathologie und Pathophysiologie aller bekannten Störungen. Zum ersten Mal enthält das Werk neue Abschnitte zu wichtigen Bereichen der Autoimmunpankreatitis und gutartigen zystischen Neoplasien. Darüber hinaus bietet diese Ausgabe hochwertige Illustrationen, Zeichnungen und Röntgenaufnahmen als Schritt-für-Schritt-Anleitungen zu sämtlichen endoskopischen und chirurgischen Verfahren. Alle Bilder können für wissenschaftliche Präsentationen aus einer Bilddatenbank heruntergeladen werden.Jedes Kapitel in der 3. Auflage von The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery wurde gründlich überarbeitet und aktualisiert. Viele Veränderungen in der klinischen Praxis seit Veröffentlichung der Vorgängerversion sind nun dokumentiert. Dazu gehören neue Leitlinien für invasive und nicht-invasive Behandlungen, neue molekularbiologische Pathways zur Unterstützung klinischer Entscheidungen für die gezielte Behandlung von Bauchspeicheldrüsenkrebs, neue minimal-invasive Ansätze zur Behandlung von Erkrankungen des Pankreas und die neuesten Erkenntnisse zu neuroendokrinen periampullären Tumoren.- Das umfassendste Werk über die Bauchspeicheldrüse, mit herausragenden und klaren Leitlinien für Kliniker.- Deckt alle Erkrankungen der Bauchspeicheldrüse detailliert ab, inkl. Anatomie, Physiologie, Pathologie, Pathophysiologie, Diagnose und Management.- Vollständig aktualisiert und um neue Kapitel erweitert.- Über 500 Illustrationen zum Herunterladen.- International renommierte Herausgeber und Autoren.Die 3. Auflage von The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery ist ein wichtiges Werk für Gastroenterologen und Chirurgen für gastrointestinale Chirurgie weltweit.

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery

Contributors xiiiPreface xxixAbbreviations xxxAbout the Companion Website xliiSection 1 Anatomy of the Pancreas 11 Development of the Pancreas and Related Structures 3Brian Lewis and Junhao Mao2 Anatomy, Histology, and Fine Structure of the Pancreas 10Daniel S. Longnecker, Fred Gorelick, and Elizabeth D. Thompson3 Congenital and Inherited Anomalies of the Pancreas 24Martin Zenker and Markus M. LerchSection 2 Physiology and Pathophysiology of Pancreatic Functions 414 Physiology of Acinar Cell Secretion 43Ole H. Petersen5 Physiology of Duct Cell Secretion 56Mei Zeng, Laura Vachel, and Shmuel Muallem6 Pathophysiology of Experimental Pancreatitis 63Vikas Dudeja, Rajinder Dawra, and Ashok K. Saluja7 Physiology and Pathophysiology of Function of Sphincter of Oddi 75Savio George Barreto and James Toouli8 Neurohormonal and Hormonal Control of Pancreatic Secretion 84Chung Owyang9 Regulation of Pancreatic Protein Synthesis and Growth 95Maria Dolors Sans and John A. Williams10 Fibrogenesis in the Pancreas: The Role of Stellate Cells 106Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson11 Fibrogenesis of the Pancreas: The Role of Macrophages 117Aida Habtezion12 Insulo-Acinar Relationship 123Keiko Shiratori and Kyoko ShimizuSection 3 Acute Pancreatitis 13313 Epidemiology and Etiology of Alcohol-Induced Pancreatitis 135Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte14 Epidemiology and Etiology of Acute Biliary Pancreatitis 146Michael G.T. Raraty, Andrea Sheel, and John P. Neoptolemos15 Genetic Factors in Acute Pancreatitis 158Zachary Zator and Georgios I. Papachristou16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis 166Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor17 The Role of Neurogenic Inflammation in Pancreatitis 173Jami L. Saloman, Kathryn M. Albers, and Brian M. Davis18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis 178Julia Mayerle, Frank Ulrich Weiss, Walter Halangk, and Markus M. Lerch19 Histopathology of Acute Pancreatitis 193Günter Klöppel20 Clinical Classification Systems of Acute Pancreatitis 199John A. Windsor and Max S. Petrov21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 204Bettina M. Rau and Guido Alsfasser22 Acute Pancreatitis Associated With Congenital Anomalies 213Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit23 Acute Pancreatitis in Children 219Mark E. Lowe and Véronique D. Morinville24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs 230Ali A. Aghdassi and Markus M. Lerch25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 238Yoshihisa TsujiClinical Course and Medical Treatment of Acute Pancreatitis 25126 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 251Timothy B. Gardner27 ICU Treatment of Severe Acute Pancreatitis 258Scott R. Gunn and David C. Whitcomb28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 265Rainer Isenmann and Mathias WittauInterventional and Surgical Management of Acute Pancreatitis 27129 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 271Thomas E. Clancy30 Management of Infected Pancreatic Necroses: An Endoscopic Approach 277Eduardo Rodrigues-Pinto and Todd H. Baron31 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 283Rebecca Saunders, Michael G.T. Raraty, Chris Halloran, and John P. Neoptolemos32 Open Surgical Debridement in Necrotizing Pancreatitis 289Lutz Schneider and Markus W. Büchler33 Endoscopic Treatment of Biliary Acute Pancreatitis 296Ichiro Yasuda, Shinpei Doi, and Masatoshi Mabuchi34 Strategies for the Treatment of Pancreatic Pseudocysts and Walled-Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 301Georg Beyer, Julia Mayerle, and Markus M. Lerch35 Strategies for the Treatment of Pancreatic Pseudocysts and Walled-Off Necrosis After Acute Pancreatitis: Surgical Treatment 305Naohiro Sata, Masaru Koizumi, and Alan K. Lefor36 Management of Fluid Collection in Acute Pancreatitis 311Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch37 Management of Pancreatic Fistula in Acute Pancreatitis 316Jörg Kaiser, Thilo Hackert, and Markus W. BüchlerLong-Term Outcome After Treatment of Acute Pancreatitis 32338 Long-Term Outcome After Acute Pancreatitis 323Christin Tjaden and Thilo HackertSection 4 Chronic Pancreatitis 33139 Molecular Understanding of Chronic Pancreatitis 333John F. Eisses and Sohail Z. Husain40 Epidemiology and Pathophysiology of Alcoholic Chronic Pancreatitis 342Atsushi Masamune and Tooru Shimosegawa41 Pain Mechanisms in Chronic Pancreatitis 349Pierluigi di Sebastiano, Tommaso Grottola, and Francesco F. di Mola42 Natural History of Recurrent Acute and Chronic Pancreatitis 355Rohit Das and Dhiraj Yadav43 Chronic Pancreatitis with Inflammatory Mass of the Pancreatic Head 365Ulrich F. Wellner and Tobias Keck44 Early Chronic Pancreatitis 371Tetsuhide Ito, Masayuki Hijioka, and Tooru Shimosegawa45 Hereditary Chronic Pancreatitis: Molecular Pattern, Clinical Consequences, and Management Principles 374Celeste Shelton and David C. Whitcomb46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 384Shailesh V. Shrikhande and Savio George Barreto47 Cystic Fibrosis (CFTR)-Associated Pancreatic Disease 391Chee Y. Ooi and Aliye Uc48 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 397Julia Mayerle, Peter Simon, and Markus M. Lerch49 Evidence of Contrast-Enhanced CT and MRI/MRCP 406J. Enrique Domínguez-Munoz, Roberto García-Figueiras, and Julio Iglesias-García50 Chronic Pancreatitis: Risk Factors in Cancer 417Albert B. Lowenfels and Patrick MaisonneuveConservative Treatment of Chronic Pancreatitis 42151 Pain Management in Chronic Pancreatitis 421Kai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, and Jakob R. Izbicki52 Medical Treatment of Chronic Pancreatitis: Pancreatic Digestive Enzymes: Lipases, Proteases 426Mark E. Lowe53 Nutritional Support of Chronic Pancreatitis 429Sinead N. Duggan and Stephen J. O'Keefe54 Medical Therapy for Chronic Pancreatitis: Antioxidants 435Chris E. ForsmarkStrategies for Endoscopic and Surgical Treatment of Chronic Pancreatitis 43955 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 439Jörg Schirra, Markus M. Lerch, and Julia Mayerle56 Indications and Goals of Surgical Treatment 449Ryan T. Groeschl and Michael B. Farnell57 Pancreatic Duct Drainage Procedure 453Dirk Bausch and Tobias Keck58 Duodenum-Preserving Pancreatic Head Resection 458Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar UhlContents vii59 Major Pancreatic Resection 467May C. Tee and Michael B. Farnell60 Laparoscopic Surgery 479Vernissia Tam, Melissa E. Hogg, and Amer ZureikatManagement of Diabetes and Long-Term Outcome of Chronic Pancreatitis 48861 Chronic Pancreatitis: Long-Term Outcome After Medical and Surgical Treatment 488Volker Aßfalg, Norbert Hüser, and Helmut Friess62 Management of Pancreatic Diabetes Secondary to Chronic Pancreatitis 495Keiko ShiratoriSection 5 Autoimmune Pancreatitis 50363 Epidemiology of Autoimmune Pancreatitis 505Terumi Kamisawa and Tooru Shimosegawa64 Pathogenesis of Autoimmune Pancreatitis 510Yoh Zen65 Histology of Autoimmune Pancreatitis 516Rajib Gupta and Vikram Deshpande66 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 520Tooru Shimosegawa, Morihisa Hirota, and Atsushi Kanno67 Clinical Manifestations of Type 2 Autoimmune Pancreatitis 534Emma L. Culver and George Webster68 Laboratory Diagnosis of Autoimmune Pancreatitis 539J.-Matthias Löhr, Pia Maier, and Stephan L. Haas69 What is the Evidence Measuring Immune Markers 544Shigeyuki Kawa70 Imaging Diagnosis of Autoimmune Pancreatitis 550Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, and Makoto Takaoka71 Medical Management of Autoimmune Pancreatitis 555Shounak Majumder and Suresh T. ChariLong-Term Outcome of Management of Autoimmune Pancreatitis 56072 Long-Term Outcome After Treatment of Autoimmune Pancreatitis 560Luca Frulloni and Nicolo de PretisSection 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 56573 Epidemiology of Cystic Neoplasms of the Pancreas 567Saurabh Mukewar and Suresh T. Chari74 Histologic Classification and Staging of Cystic Neoplasms 573Noriyoshi Fukushima and Giuseppe Zamboni75 Molecular Mechanisms of Cystic Neoplasia 580Nickolas Papadopoulos and Ralph H. Hruban76 Clinical Presentation of Cystic Neoplasms 589Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao77 Evaluation of Cystic Lesions Using EUS, MRI, and CT 593Anne Marie Lennon and Hiroyuki Maguchi78 Cytologic Evaluation of Cystic Neoplasms 603Martha Bishop Pitman79 Natural History of Cystic Neoplasms: IPMN, MCN, SCN, and SPN 611Anna-Katharina Stadler, Thilo Hackert, Stefan Fritz, and Markus W. Büchler80 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasms 618Klaus Sahora and Carlos Fernández- del CastilloLocal and Standard Surgical Treatment of Cystic Neoplasms 62281 Duodenum-Preserving Partial or Total Pancreatic Head Resection 622Hans G. Beger and Bertram Poch82 Pancreatic Middle Segment Resection 627Calogero Iacono83 The Indications For and Limitations of Tumor Enucleation 632Rosalie A. Carr, C. Max Schmidt, and Henry A. Pitt84 Standard Surgical Management of IPMN, MCN, SPN, and SCN Lesions: Open Approach 641Miral Sadaria Grandhi, Barish H. Edil, and Richard D. Schulick85 Surgical Treatment of Cystic Neoplasms: Laparoscopic Approach 649Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, and Thilo Hackert86 Management of Recurrence of Cystic Neoplasms 655Zhi Ven Fong, Christopher L. Wolfgang, and Keith D. LillemoeLong-Term Outcome of Management of Cystic Neoplasms 66087 Long-Term Outcome After Observation and Surgical Treatment: What is the Evidence? 660Giovanni Marchegiani, Giuseppe Malleo, and Claudio BassiSection 7 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer 66588 Epidemiology of Pancreatic Cancer 667Evelina Mocci and Alison P. Klein89 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data 673Uwe A. Wittel, Bradley R. Hall, and Surinder K. Batra90 Molecular Understanding of Development of Ductal Pancreatic Cancer 679Laura D. Wood and Ralph H. Hruban91 Familial Pancreatic Cancer 688Alison P. Klein92 Pathology of Exocrine Pancreatic Tumors 693Meredith E. Pittman and Ralph H. Hruban93 Pancreatic Cancer: Precancerous Lesions 705Michaël Noë, Lodewijk A.A. Brosens, and Johan Offerhaus94 Clinical History and Risk Factors of Pancreatic Cancer 717Norbert Hüser, Volker Aßfalg, and Helmut Friess95 Pancreatic Cancer Within the Uncinate Process: Radiologic and Clinical Characteristics 724Sebastian Holländer and Dieter Birk96 The Role of EUS in the Diagnosis and Differential Diagnosis of Neoplastic Lesions 728Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao97 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI 733Siva P. Raman and Elliot K. Fishman98 Screening of Patients with Hereditary Pancreatic Cancer 745Michael Goggins99 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence 755Norbert Hüser, Volker Aßfalg, Isabel Rauscher, and Helmut Friess100 Tumor Markers in Pancreatic Malignancies 762Shin Hamada, Atsushi Masamune, and Tooru Shimosegawa101 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer 766Kyoichi Takaori and Shinji Uemoto102 Clinical Assessment and Staging of Advanced Pancreatic Cancer 770Jennifer LaFemina, Ann K. Friedrich, and Giles F. WhalenSurgical Treatment of Pancreatic Cancer 776103 Pancreatic Cancer: Indications for Resection 776Akimasa Nakao104 Pancreaticoduodenectomy for Pancreatic Cancer, Short- and Long-Term Outcomes After Kausch-Whipple and Pylorus-Preserving Resection 783Jin He and John L. Cameron105 Left Pancreatectomy for Body and Tail Cancer 790Georgios Gemenetzis and Christopher L. Wolfgang106 Total Pancreatectomy: Indications and Limitations 797Seiko Hirono and Hiroki Yamaue107 Laparoscopic and Robotic Resection for Pancreatic Cancer 804Deepa Magge, Herbert J. Zeh, and Melissa E. Hogg108 Extended Radical Surgery for Pancreatic Cancer 814Thilo Hackert, Alexis Ulrich, and Markus W. Büchler109 Palliative Pancreatoduodenectomy: Benefits and Limitations 823Christoph W. Michalski, Max Heckler, Mert Erkan, and Markus W. Büchler110 Bypass Surgery for Advanced Pancreatic Cancer 828Jürgen Weitz, Thomas Pausch, Christoph W. Michalski, and Thilo HackertNonsurgical Palliation of Pancreatic Cancer 835111 Endoscopic and Interventional Palliation of Pancreatic Cancer 835Takao ItoiMedical Treatment of Pancreatic Cancer 842112 Neoadjuvant Treatment of Pancreatic Cancer: Downstaging Results 842Robert A. Wolff and Gauri Varadhachary113 Adjuvant Chemotherapy in Pancreatic Cancer 847Robert P. Jones, Paula Ghaneh, and John P. Neoptolemos114 Immunotherapy for Pancreatic Cancer 856Adrian G. Murphy, Elizabeth M. Jaffee, and Lei Zheng115 Targeted Therapies for Pancreatic Cancer 865Vincent Bernard and Anirban Maitra116 Palliative Chemotherapy for Advanced Pancreatic Cancer: Survival Benefit and Side Effects of Treatment 872Olusola O. Faluyi, Madhuchanda Chatterjee, and Daniel H. Palmer117 Management of Pain in Pancreatic Cancer 879Michael Erdek, Indy Wilkinson, and Zackary E. Boomsaad118 Role of Radio and Proton Beam Therapy for Pancreatic Cancer 886Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, and Joseph M. Herman119 Management of Cancer Recurrence 895Oliver Strobel and Markus W. BüchlerLong-Term Outcome After Treatment of Pancreatic Cancer 906120 Survival and Late Morbidity After Resection of Pancreatic Cancer 906Avinoam Nevler, Charles J. Yeo, and Jordan M. WinterSection 8 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 919121 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas 921J.J. Mukherjee, Kok-Onn Lee, and Gregory Kaltsas122 Pathology of Neuroendocrine Neoplasms 930Atsuko Kasajima and Hironobu Sasano123 Molecular Genetics of Neuroendocrine Tumors 937Nickolas Papadopoulos and Ralph H. Hruban124 Clinical Manifestation of Endocrine Tumors of the Pancreas 947Ken Kawabe and Tetsuhide Ito125 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas 953Kok-Onn Lee, Gregory Kaltsas, and J.J. Mukherjee126 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes 961Anja Rinke and Thomas Matthias Gress127 Nonfunctioning Pancreatic Neuroendocrine Tumors: Diagnosis and Management Principles 967Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura128 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas 972Gregory Kaltsas, J.J. Mukherjee, and Kok-Onn Lee129 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors 979Takao Ohtsuka, Hideyo Kimura, and Masafumi NakamuraSurgical Management of Endocrine Tumors of the Pancreas 982130 Surgical Treatment of Endocrine Tumors: Enucleation 982Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens131 Local Treatment of Endocrine Tumors: Duodenum-Preserving Partial or Total Pancreatic Head Resection and Pancreatic Middle-Segment Resection 989Hans G. Beger and Wataru Kimura132 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection 994Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens133 Management of Insulinoma 1002Keijiro Ueda, Linkaku Lee, and Tetsuhide Ito134 Evidence of Medical and Surgical Treatment of Gastrinoma 1009Ryuichiro Doi135 Rare Neuroendocrine Tumors of the Pancreas: Management and Evidence of Surgical Treatment 1013Ryuichiro Doi136 Treatment of Neuroendocrine Tumors of the Pancreas and Biliary Tract 1019Andrea Frilling, Ashley K. Clift, and Vito CincinnatiLong-Term Outcome After Treatment of Neuroendocrine Tumors of the Pancreas 1029137 Long-Term Outcome After Treatment of Endocrine Tumors 1029Andreas Machens and Henning DralleSection 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer 1035138 Periampullary Cancer: Clinical Presentation and Diagnostic Strategies 1037Amanda B. Cooper and Keith D. Lillemoe139 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum 1047Yue Xue, Michelle D. Reid, and N. Volkan Adsay140 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management 1058Omer Basar and William R. Brugge141 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations 1068Natsuyo Yamamoto, Hiroyuki Isayama, and Kazuhiko Koike142 Surgical Treatment of Adenoma and Cancer of Papilla of Vater 1074Hans G. Beger, Bertram Poch, and Bettina M. Rau143 Surgical Treatment of Duodenal Cancer 1081Fuyuhiko Motoi and Michiaki Unno144 Surgical Treatment of Distal Cholangiocarcinoma 1083Yukihiro Yokoyama, Tomoki Ebata, and Masato Nagino145 Adjuvant and Palliative Chemotherapy of Periampullary Cancers 1089Eyas Mohamed, Paula Ghaneh, and John P. NeoptolemosLong-Term Survival After Tumor Resection 1097146 Long-Term Survival After Resection of Periampullary Cancer 1097Masayuki Ohtsuka and Masaru MiyazakiSection 10 Transplantation of the Pancreas 1107147 Transplantation of Pancreatic Islets 1109Bernhard J. Hering and Melena D. Bellin148 Transplantation of the Pancreas 1121Hans W. Sollinger and Dixon B. KaufmanIndex 1129