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Bacterial Resistance to Antibiotics - From Molecules to Man

Bacterial Resistance to Antibiotics - From Molecules to Man

Autorzy
Wydawnictwo John Wiley and Sons Ltd
Data wydania 2019
Liczba stron 288
Forma publikacji książka w miękkiej oprawie
Poziom zaawansowania Dla profesjonalistów, specjalistów i badaczy naukowych
Język angielski
ISBN 9781119940777
Kategorie Nauka ekologiczna, biosfera
244.65 PLN (z VAT)
$55.03 / €52.45 / £45.53 /
Produkt na zamówienie
Dostawa 5-6 tygodni
Ilość
Do schowka

Opis książki

AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS


Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths.


Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era-when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death-new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics.


Bacterial Resistance to Antibiotics - From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more.





Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability

Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance

Includes an overview of the genetic and molecular mechanisms of antibiotic resistance

Addresses contemporary issues of global public health and longevity

Includes full references, author remarks, and color illustrations, graphs, and charts



Bacterial Resistance to Antibiotics - From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.

Bacterial Resistance to Antibiotics - From Molecules to Man

Spis treści

List of Contributors vii





Preface ix





Foreword xiii

Ada Yonath





1 Molecular Mechanisms of Antibiotic Resistance - Part I 1

Alison J. Baylay, Laura J.V. Piddock, and Mark A. Webber





2 Molecular Mechanisms of Antibiotic Resistance - Part II 27

Liam K.R. Sharkey and Alex J. O'Neill





3 Resistance to Glycopeptide Antibiotics 51

Francois Lebreton and Vincent Cattoir





4 Resistance and Tolerance to Aminoglycosides 81

Wendy W.K. Mok and Mark P. Brynildsen





5 Tetracyclines: Mode of Action and their Bacterial Mechanisms of Resistance 101

Marilyn C. Roberts





6 Fluoroquinolone Resistance 125

Karl Drlica, Xilin Zhao, Muhammad Malik, Hiroshi Hiasa, Arkady Mustaev, and Robert Kerns





7 Dihydropteroate Synthase (Sulfonamides) and Dihydrofolate Reductase Inhibitors 163

Clemente Capasso and Claudiu T. Supuran





8 Anti?tuberculosis Agents 173

Ying Zhang





9 Multidrug Resistance 201

Robert L. Marshall and Vassiliy N. Bavro





10 Anti?virulence Therapies Through Potentiating ROS in Bacteria 239

Kristin J. Adolfsen and Mark P. Brynildsen





Index 255

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