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Development and Application of Biomarkers

Development and Application of Biomarkers

Autorzy
Wydawnictwo Taylor & Francis Inc
Data wydania 28/10/2010
Liczba stron 297
Forma publikacji książka w twardej oprawie
Poziom zaawansowania Dla profesjonalistów, specjalistów i badaczy naukowych
Język angielski
ISBN 9781439819791
Kategorie Białka
1 140.30 PLN (z VAT)
$256.51 / €244.48 / £212.23 /
Produkt na zamówienie
Dostawa 5-6 tygodni
Ilość
Do schowka

Opis książki

First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. In biomedical science, biomarker has evolved to most commonly mean a characteristic that can be used either as a diagnostic or a prognostic, but most significantly as a screening indicator for pathologies that tend to be somewhat silent prior to overt clinical display.





Applying scientific rigor, as well as a disciplined approach to nomenclature, Roger Lundblad's Development and Application of Biomarkers rationalizes the current enthusiasm for biomarkers with the use of well-established clinical laboratory analytes in clinical medicine. Highly respected for his work as both a classical protein scientist and as a pioneer in proteomics, Dr. Lundblad catalogs various biomarkers recognized in clinical medicine and, where possible, matches the expectations for advances in screening technologies with the realities of statistical analysis. More specifically, this important reference:











Details an extensive list of biomarkers for various stages of a number of cancer types including ovarian, pancreatic, prostate, and breast cancer
Looks at how proteomics is used for the discovery and validation of biomarkers
Explores the use of microarray technology, ultra-high performance liquid chromatography, and computational bioinformatic approaches for the discovery and use of biomarkers
Examines the use of cells and cell fragments as more complex biomarkers
Organizes a host of significant biomarkers and essential research by type and use in a series of readily accessible tables








Throughout this volume, Dr. Lundblad encourages consideration of biomarkers more as a concept than as laboratory analytes, emphasizing the relation between the discovery of a biomarker and the biology underlying its production. Ultimately, it is a thorough understanding of that underlying biology that will lead to the development of assays that are robust and reproducible, as well as clinically significant.

Development and Application of Biomarkers

Spis treści

Introduction to Biomarkers

Application of Biomarkers in Diagnostics, Prognostics, Theranostics, and Personalized Medicine

Introduction

Nomenclature/Definitions

Biomarkers and Diagnostics

Biomarkers and Screening

Biomarkers and Prognosis

Biomarkers and Theranostics and Personalized Medicine

Biomarkers and Specific Pathologies

Rheumatoid Arthritis

Inflammation Biomarkers in Different Pathologies

Biomarkers in Ophthalmology

Biomarkers in Neurology

Cardiac Biomarkers

Biomarkers in Renal Disease

Biomarkers for Bone

Biomarkers for Exposure to Environmental Toxins

Biomarkers and the Development of Biopharmaceuticals

Development of Biomarkers for Oncology

Intermediate Biomarkers and the Precancerous Condition

Cancer and Inflammation

Head and Neck Cancer

Ovarian Cancer

Pancreatic Cancer

Prostate Cancer

Breast Cancer

The Use of Proteomics to Discover Biomarkers

Blood

Urine

Saliva

Miscellaneous Biological Fluids/Excretory Products as Sources of Biomarkers

Biomarkers in Tissue Samples

Modified Proteins, Oligosaccharides, and Oligonucleotidesas Biomarkers

Complex Biomarkers: Cells, Cell Membrane Proteins, and Cell Fragments as Biomarkers

Use of Microarray Technology in Biomarker Discovery and Development

Development of Assays for Biomarkers

Appendix A: Model Standard Operating Procedure for an Assay





references provided at the end of every chapter

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