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Cardiac Electrophysiology: From Cell to Bedside

Cardiac Electrophysiology: From Cell to Bedside

Wydawnictwo W.B. Saunders Company
Data wydania 01/10/2013
Wydanie 6
Liczba stron 1392
Forma publikacji książka w twardej oprawie
Poziom zaawansowania Dla profesjonalistów, specjalistów i badaczy naukowych
Język angielski
ISBN 9781455728565
Kategorie Medycyna układu krążenia
983.00 PLN (z VAT)
$252.76 / €226.17 / £209.48 /
Produkt dostępny
Przesyłka w 2 dni
Do schowka

Opis książki

2014 BMA Medical Book Awards Highly Commended in Cardiology category! Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald's Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued. "This book uniquely provides a comprehensive review of basic science concepts of electrophysiology that are later translated into practical clinical terms. This edition i

Cardiac Electrophysiology: From Cell to Bedside

Spis treści

Part I. Structural and Molecular Bases of Ion Channel Function

1 Voltage-Gated Sodium Channels and Electrical Excitablility of the Heart

2 Calcium Channels in the Heart

3 Voltage-Regulated Potassium Channels

4 Structural and Molecular Bases of Inward Rectifier Potassium Channel Function

5 Mammalian Calcium Pumps in Health and Disease

6 Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function

7 Structural and Molecular Bases of Mitochondrial Ion Channel Function

8 Molecular Organization, Gating, and Function of Gap Junction Channels

Part II. Biophysics of Cardiac Ion Channel Function

9 Biophysics of Normal and Abnormal Cardiac Sodium Channel Function

10 Regulation of Cardiac Calcium Channels

11 KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease

12 Structural Determinants and biophysical properties of hERG channel gating

13 Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents

14 Cardiac Stretch-Activated Channels and Mechano-Electric Coupling

15 Biophysical Properties of Gap Junctions

16 Excitation-Contraction Coupling

Part III. Intermolecular Interactions and Cardiomyocyte Electrical Function

17 Ion Channel Trafficking in the Heart

18 Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5

19 Calmodulin and CaMKII as Ca2+ switches for cardiac ion channels

20 Macromolecular Complexes and Cardiac Potassium Channels

21 Reciprocity of Cardiac Sodium and Potassium channels in the control of Excitability and Arrhythmias

22 The Intercalated Disc: A Molecular Network that Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability

23 Scaffolding Proteins and Ion Channel Diseases

24 Epigenetics in Cardiac Rhythm Diseases

Part IV. Cell Biology of Cardiac Impulse Initiation and Propagation

25 Cardiac Impulse is Initiated by a Coupled System of Membrane Ion Channels and Ca2+ Cycling Proteins

26 Biological Pacing

27 Intercellular Communication and Impulse Propagation

28 Mechanisms of Atrioventricular Nodal Excitability and Propagation

29 Cell Biology of the Specialized Cardiac Conduction System

30 Cardiac Fibroblasts and Arrhythmogenesis

Part V. Models of Cardiac Excitation

31 Ionic Mechanisms of Atrial Action Potentials

32 Models of the Ventricular Action Potential in Health and Disease

33 Calcium Signaling in a Cardiomyocyte Models with Realistic Geometries

34 Theory of Rotors and Arrhythmias

35 Supraventricular Arrhythmias i

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