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The timely volume describes recent discoveries and method developments that have revolutionized Structural Biology with the advent of X-ray Free Electron Lasers. It provides, for the first time, a comprehensive examination of this cutting-edge technology. It discusses of-the-moment topics such as growth and detection of nanocrystals, Sample Delivery Techniques for serial femtosecond crystallography, data collection methods at XFELs, and more. This book aims to provide the readers with an overview of the new methods that have been recently developed as well as a prospective on new methods under development. It highlights the most important and novel Structural Discoveries made recently with XFELS, contextualized with a big-picture discussion of future developments.

X-ray Free Electron Lasers: A Revolution in Structural Biology

1. X-ray Free Electron Lasers and their applications 2. Serial Femtosecond Crystallography (SFX): An Overview 3. Small is Beautiful: Growth and Detection of Nanocrystals 4. The lipid cubic phase as a medium for the growth of membrane protein microcrystals 5. Sample Delivery Techniques for Serial Crystallography 6. When diffraction stops and destruction begins 7. Climbing the data mountain: processing of SFX data 8. Phasing XFEL serial crystallography data 9. Structure Determination by Continuous Diffraction from Imperfect Crystals 10. Advances in structure determination of G protein-coupled receptors by SFX 11. Time-resolved serial femtosecond crystallography, towards molecular movies of biomolecules in action 12. Towards Molecular Movies of Enzymes 13. X-ray Spectroscopy with XFELs 14. Single molecule imaging using X-ray free electron lasers 15. The use of angular correlations to extract 3-dimensional structural information from X-ray solution scattering 16. Future Directions of High Repetition Rate X-ray Free Electron Lasers Index