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This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains. Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.

Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

Contents

Listof Contributors

PartI: Immunohistology of Epithelial Tumors

1  Immunohistology and Molecular Studiesof Epithelial Tumors

      Heather M. Froehlich and Jose A.Plaza

Part II: AdnexalNeoplasms

2  Immunohistology and Molecular Studiesof Sweat Gland Tumors

      Ana M. Molina-Ruiz, Laura Fuertes,and Luis Requena

3  Immunohistology and Molecular Studiesof Follicular Tumors

      Olayemi Sokumbi and Jose A. Plaza

4  Use of Immunohistochemical andMolecular Studies in the Evaluation of the Sebaceous Neoplasms

       Doina Ivan, Victor G. Prieto, andPhyu P. Aung

 

Part III:Immunohistology of Cutaneous Metastases and Its Simulators

5  Cutaneous Metastasis

      Danielle M. Wehle, Sadia Salim, andMartin A. Sangueza

 

Part IV:Immunohistology of Mesenchymal Neoplasms

6  Immunohistology and Molecular Studiesof Fibrohistiocytic and Myofibroblastic Cutaneous Tumors

     Danny Ghazarian, Sebastien Labonte,Brendan Craig Dickson, and Ayman Al Habeeb

7  Immunohistology and Molecular Studiesof Smooth Muscle and Neural Cutaneous Tumors

     Tammie Ferringer

8  New Insights in Vascular LesionsDevelopment and Identification with Immunohistochemical Markers

      Omar P.Sangüezaand Julio A. Diaz-Perez

 

Part V:Immunohistology of Cutaneous Lymphoma

9  Immunohistology and Molecular Studiesof Cutaneous B-cell Lymphomas

      Juan F. García

10  Immunohistology and Molecular Studies ofCutaneous T-cell Lymphomas and Mimics

    Carlos A. Torres-Cabala, Phyu P.Aung, Roberto N. Miranda, and Jonathan L. Curry

11  Immunohistology of Leukemia Cutis andHistiocytic Tumors

      Maria Teresa Fernández Figueras,Gustavo Tapia, José Luis Mate, Aurelio Ariza

 

Part VI:Immunohistology of Melanocytic Lesions

 

12  Immunohistology of Melanocytic Lesions

       Jonathan L. Curry, Michael T.Tetzlaff, Priyadharsini Nagarajan, and Carlos A. Torres-Cabala

 

Part VII:Molecular Studies of Melanocytic Lesions

 

13  Molecular Studies of Melanocytic Lesions

      Rami Al-Rohil, PriyadharsiniNagarajan, and Michael T. Tetzlaff

 

Part VIII:Immunohistology of Sentinel Lymph Node in Melanoma

 

14  Sentinel Lymph Node in Melanoma

       Victor G. Prieto