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Molecular and Cellular Biomechanics

Molecular and Cellular Biomechanics

Autorzy
Wydawnictwo Pan Stanford Publishing Pte Ltd
Data wydania 18/03/2015
Liczba stron 232
Forma publikacji książka w twardej oprawie
Poziom zaawansowania Literatura popularna
Język angielski
ISBN 9789814316835
Kategorie Biomechanika, kinetyka człowieka
696.15 PLN (z VAT)
$156.60 / €149.25 / £129.57 /
Produkt na zamówienie
Dostawa 5-6 tygodni
Ilość
Do schowka

Opis książki

This book bridges the gap between life sciences and physical sciences by providing several perspectives on cellular and molecular mechanics on a fundamental level. It begins with a general introduction to the scales and terms that are used in the field of cellular and molecular biomechanics and then moves from the molecular scale to the tissue scale. It discusses various tissues or cellular systems through the chapters written by prominent engineers and physicists working in various fields of biomechanics.





"Big picture" items, such as the number of atoms in cells and the number of cells in an organism, are discussed, followed by several of the physical laws that play a central role in nanoscale biomechanics, including the mechanics of the nucleus and its associated molecules. The book provides several case studies in atomic force microscopy and examines the physical relationship between living cells and laboratory substrata. It delves deeply into the molecular mechanisms of axonal growth, transport, and repair and provides a mechanistic framework for understanding the underlying molecular conditions that contribute to heart disease. While the quantitative and straightforward language of the book will help the engineering community grasp the concepts better and utilize them effectively, the questions given in each chapter will encourage upper-level undergraduate students, graduate students, or those generally interested in understanding cellular and molecular mechanics to dig deeper into the material. The complimentary solutions manual is available for qualified instructors upon request.

Molecular and Cellular Biomechanics

Spis treści

Introduction





Brief overview of numbers and scales





History of cell mechanics





Outline of the book





Problems





Mechanics of Single Molecules and Single Proteins





Macromolecules, small molecules, and machines: How are they alike? How do they differ?





Thermal energy, equipartition, and the Boltzmann distribution





Thermal ratchets: what are they? A practical definition





Detailed balance





Entropy and enthalpy





Two ways to model a chemomechanical transition: macromechanical view versus statistical mechanics view - when do they apply?





Conclusions





Problems





Nucleus Mechanics





DNA





Lamins





Whole nucleus properties





Problems





Nanoscale Imaging and Modeling





The structures of entropy partitioning





Atomic force microscopy





Further Considerations





Questions





Cell-substrate Interactions





Introduction





Effect of substrate stiffness and matrix ligand on cell morphology





Morphology: Integration of biochemical and biophysical factors





Effect of substrate stiffness and matrix ligand on cell motility





Motility: Integration of biochemical and biophysical factors





Effect of substrate stiffness and matrix ligand on cell mechanics





Cell mechanics: Integration of biochemical and biophysical factors





Changes in substrate stiffness in disease





Cell-Substrate Mechanics: Conclusions





Axonal Transport and Neuromechanics





Introduction





Structural organization within the neuron





Axonal Transport of the Cytoskeleton





Neuromechanics





Summary and Outlook





Implications for Disease - Valvular Fibrosis and the Myofibroblast





Introduction





The Myofibroblast





Mechanical Regulation of Valvular Fibrosis





Conclusions





Index





References

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