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This book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. It is composed of 12 chapters written by pioneers in microbial, biotech, and cancer research.

Microbial Infections and Cancer Therapy

Bifidobacterium as a Delivery System of Functional Gene for Cancer Gene Therapy





Chao Han, Yu-qing Dai, Zi-chun Hua, Geng-Feng Fu, Yan Yin, Bi Hu, and Gen-xing Xu











Therapy with Oncolytic Clostridium novyi-NT: From Mice to Men





Shibin Zhou











Genetic Engineering of Clostridial Strains for Cancer Therapy





Maria Zygouropoulou, Aleksandra Kubiak, Adam V. Patterson, and Nigel P. Minton











Bacteria-Derived Alternatives to Live Mycobacterium bovis Bacillus Calmette-Guerin for Non-Muscle Invasive Bladder Cancer Treatment





Esther Julian and Estela Noguera-Ortega











Genetically Modified Salmonella as Cancer Therapeutics: Mechanisms, Advances and Challenges





Xiaoxin Zhang and Zi-Chun Hua











Genetically Engineered Oncolytic Salmonella typhimurium





Jin Hai Zheng and Jung-Joon Min











Engineering E. coli to Combat Cancer





Carlos Pinero-Lambea, David Ruano-Gallego, Gustavo Bodelon, Beatriz Alvarez, and Luis Angel Fernandez











Live P. aeruginosa as Cancer Vaccine Vector





Y. Wang, B. Polack, and B. Toussaint











The Anticancer Potential of the Bacterial Protein Azurin and Its Derived Peptide P28





Ana Rita Garizo, Nuno Bernardes, Ananda M. Chakrabarty, and Arsenio M. Fialho











Bacteriocins: From Antimicrobial to Potencial Anticancer Agents





Ligia Coelho, Nuno Bernardes, and Arsenio M. Fialho











Bacteriocins as Anticancer Peptides? A Biophysical Approach





Filipa Dias de Oliveira, Miguel A. R. B. Castanho, and Diana Gaspar











Where Cancer and Bacteria Meet





Alexandra Merlos, Ricardo Perez-Tomas, Jose Lopez-Lopez, and Miguel Vinas