The American Journal of Pathology, official journal of the American Society for Investigate Pathology, seeks to publish high-quality original papers on the cellular and molecular mechanisms of disease. The editors accept manuscripts which report important findings on disease pathogenesis or basic biological mechanisms that relate to disease, without preference for a specific method of analysis. High priority is given to: a) studies on human disease and relevant experimental models using cellular, molecular, biological, chemical and immunological approaches in conjunction with morphology; b) work involving transgenic and knockout animal models; and c) reports of new techniques in the study of disease pathogenesis and in molecular diagnosis.