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The leading guide to the principles and clinical applications of evidence-based medicine--updated with new examples and new chaptersA Doody's Core Title for 2019!



Revised and updated to reflect the latest in medical research and evidence-based resources
Practical focus and organization to guide clinicians through the fundamentals of using the medical literature to the more advanced strategies and skills for use in patient care, using the key questions to assess any new research:

What are the results?
How serious is the risk of bias?
How do I apply the results to patient care?


Updated real-world examples drawn from the medical literature
New chapters that reflect the changing complexity of medical research and literature, including genetic association studies, systematic reviews and meta-analyses, network meta-analysis, noninferiority trials, quality improvement, and evidence-based medicine and the theory of knowledge
New emphasis on understanding the role of patient preferences and preappraised resources that provide updated evidence and evidence-based recommendations for practice

Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice, 3E

Foreword

Preface

The Foundations

1 How to Use the Medical Literature-and This Book-to Improve Your Patient Care

2 What Is Evidence-Based Medicine?

3 Evidence-Based Medicine and the Theory of Knowledge

4 What Is the Question?

5 Finding Current Best Evidence

6 Why Study Results Mislead: Bias and Random Error

Therapy

7 Therapy (Randomized Trials)

8 How to Use a Noninferiority Trial

9 Does Treatment Lower Risk? Understanding the Results

10 Confidence Intervals: Was the Single Study or Meta-analysis Large Enough?

11 Advanced Topics in the Risk of Bias of Therapy Trials

11.1 An Illustration of Bias and Random Error

11.2 Surprising Results of Randomized Trials

11.3 Randomized Trials Stopped Early for Benefit

11.4 The Principle of Intention to Treat and Ambiguous Dropouts

11.5 N-of-1 Randomized Clinical Trials

11.6 Clinical Decision Support Systems

11.7 How to Use an Article About Quality Improvement

12 Advanced Topics in the Results of Therapy Trials

12.1 Hypothesis Testing

12.2 Understanding the Results: More About Odds Ratios

12.3 What Determines the Width of the Confidence Interval?

12.4 Composite End Points

12.5 Measuring Patients' Experience

13 Advanced Topics in Applying the Results of Therapy Trials

13.1 Applying Results to Individual Patients

13.2 Numbers Needed to Treat

13.3 Misleading Presentations of Clinical Trial Results

13.4 Surrogate Outcomes

13.5 Qualitative Research

Harm (Observational Studies)

14 Harm (Observational Studies)

15 Advanced Topics in Harm

15.1 Correlation and Regression

Diagnosis

16 The Process of Diagnosis

17 Differential Diagnosis

18 Diagnostic Tests

19 Advanced Topics in Diagnosis

19.1 Spectrum Bias

19.2 Examples of Likelihood Ratios

19.3 Measuring Agreement Beyond Chance

19.4 Clinical Prediction Rules

Prognosis

20 Prognosis

21 Advanced Topics in Prognosis

21.1 How to Use an Article About Genetic Association

Summarizing the Evidence

22 The Process of a Systematic Review and Meta-analysis

23 Understanding and Applying the Results of a Systematic Review and Meta-analysis

24 Network Meta-analysis

25 Advanced Topics in Systematic Reviews

25.1 Fixed-Effects and Random-Effects Models

25.2 How to Use a Subgroup Analysis

Moving From Evidence to Action

26 How to Use a Patient Management Recommendation: Clinical Practice Guidelines and Decision Analyses

27 Decision Making and the Patient

28 Advanced Topics in Moving From Evidence to Action

28.1 Assessing the Strength of Recommendations: The GRADE Approach

28.2 Economic Analysis

28.3 Recommendations About Screening

28.4 Understanding Class Effects

28.5 Evidence-Based Practitioners and Evidence-Based Care

29 Teachers' Guides to the Users' Guides

Glossary

Index