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The Union for International Cancer Control's (UICC) TNM classification system is the most widely used cancer classification and staging system in the world. It is used to describe the anatomical extent of disease and it is essential to patient care, research and cancer control.



This fifth edition of the TNM Supplement: A Commentary of Uniform Use offers practitioners a wealth of material intended to complement the system's day-to-day use. The volume features:





Updated definitions of terms used in cancer staging.

New sections on carcinomas of the thymus, sarcomas of the spine and pelvis and soft tissue sarcomas of the head and neck, and comprehensive updates to the head and neck carcinomas, carcinomas of the lung and neuroendocrine tumours sections.

Frequently asked questions from the UICC helpdesk.






The Supplement may be treated as a companion text to the recent eighth edition of the TNM Classification of Malignant Tumours (978-1-119-26357-9), supporting the correct and uniform application of the TNM classification system. The TNM Supplement can also be utilised as a standalone book, providing explanations and examples to answer many questions that arise during the daily use of the TNM cancer classification and staging system, particularly in unusual cases.

TNM Supplement - A Commentary on Uniform Use 5e

Preface viii





Organizations Associated with the TNM System xiii





National Committees xiii





Acknowledgements xv





Abbreviations xvi





Chapter 1 Explanatory Notes - General





The General Rules of the TNM System 1





The TNM Clinical and Pathological Classifications 7





Residual Tumour (R) Classification 15





Additional Descriptors 20





Optional Descriptors 24





Unknown Primary 25





Staging of Tumours for Which No TNM Classification is Provided 25





Histopathological Grading 26





References 28





Chapter 2 Explanatory Notes - Specific Anatomical Sites





Head and Neck Tumours 34





Digestive System Tumours 54





Lung, Pleural and Thymic Tumours 85





Bone Tumours 104





Soft Tissue Tumours 106





Gastrointestinal Stromal Tumour (GIST) 108





Skin Tumours 110





Breast Tumours 118





Gynaecological Tumours 122





Urological Tumours 131





Ophthalmic Tumours 142





Hodgkin and Non?Hodgkin Lymphomas 149





References 150





Chapter 3 Site?Specific Requirements for pT and pN





Introduction 157





Head and Neck Tumours 160





Digestive System Tumours 166





Lung and Pleural Tumours 173





Tumours of Bone and Soft Tissues 176





Skin Tumours 179





Breast Tumours 183





Gynaecological Tumours 185





Urological Tumours 188





Adrenal Cortex Tumours 192





Ophthalmic Tumours 193





Hodgkin and Non?Hodgkin Lymphomas 195





References 196





Chapter 4 New TNM Classifications Recommended for Testing and Other Classifications





Introduction 198





General 198





Specific 198





Non Upper Aerodigestive Tract Mucosal Melanoma 199





Primary Liver Carcinoma of Infants and Children/Hepatoblastoma 200





Primary Cutaneous Lymphomas 202





Cutaneous T?Cell Lymphomas 202





Primary Cutaneous Lymphomas 203





Histopathologic Staging of Lymph Nodes in Mycosis Fungoides and Sezary Syndrome 204





Primary Cutaneous B?Cell/T?Cell Lymphoma (Non?MF/SS Lymphoma) 206





Multiple Myeloma 207





Leukaemia 208





References 208





Chapter 5 Optional Proposals for Testing New Subcategories of TNM





All Tumour Sites 210





Head and Neck Tumours 210





Digestive System Tumours 211





Lung Tumours 213





Breast Tumours (ICD?0?3 C50) 214





Gynaecological Tumours 215





Urological Tumours 215





References 216





Chapter 6 Frequently Asked Questions





General Questions 218





Site?Specific Questions 229





References 289





Index 291





Plate section facing p. 48