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The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary.

The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing.

The first chapter will be completely new - placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years - from new advances in growth hormones to pituitary tumor therapy.

Presents a comprehensive, translational source of information about the pituitary in one reference work
Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches
Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders
Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches

The Pituitary

Section 1 Hypothalamic-Pituitary Function

1. Functional Anatomy of the Hypothalamic Pituitary Axis

Shlomo Melmed, Cedars-Sinai Medical Center, Los Angeles

2. Adrenocorticotropin

Mark A. Herman, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas

Joseph A. Majzoub, Children's Hospital, Harvard Medical School, Division of Endocrinology, Boston

3. Growth Hormone

Vivien S. Herman-Bonert, UCLA School of Medicine, Division of Endocrinology, Los Angeles

Shlomo Melmed, Cedars-Sinai Medical Center, Los Angeles

4. Prolactin

Mark E. Molitch, Northwestern University Medical School, Center for Endocrinology, Metabolism, and Molecular Medicine

5. Thyroid-stimulating Hormone

Chester E. Ridgway, University of Colorado Health Sciences Center, Division of Endocrinology

6. Follicle-stimulating Hormone and Leutinizing Hormone

Ronald S. Swerdloff, Harbor/UCLA Medical Center, UCLA School of Medicine, Division of Endocrinology

Shalender Bhasin, Drew University School of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine

7. The Posterior Pituitary

Daniel G. Bichet, University of Montreal, Department of Medicine, Montreal

Section 2 Hypothalamic-Pituitary Dysfunction

8. The Hypothalamus

Glenn D. Braunstein, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles

9. Anterior Pituitary Failure

Charles F. Abboud, Mayo Clinic, Mayo Medical School, Rochester

Sect. 3 Pituitary Tumors

10. Pituitary Surgery

Rudolf Fahlbusch, Professor of Neurosurgery, University of Erlangen-Nurnberg, Germany

11. Radiation and Non-surgical Management of the Pituitary

Laurence Katznelson, Stanford University School of Medicine, Department of Neurosurgery, Stanford

12. Acromegaly

Shlomo Melmed, Cedars-Sinai Medical Center, Los Angeles

13. Prolactinoma

Mark E. Molitch, Northwestern University Medical School, Center for Endocrinology, Metabolism, and Molecular Medicine

14. Cushing's Disease

Lynn Loriaux , Oregon Health & Science University, Chair, Department of Medicine, Portland

Jean-Pierre Luton, Professor of Endocrinology, Cochin Medical School, University Rene Decartes, Paris, France

15. Thyrotropin-secreting Pituitary Tumors

Shlomo Melmed, Cedars-Sinai Medical Center, Los Angeles

16. Gonadotroph Adenomas

Margaret E. Wierman, University of Colorado Health Sciences Center, Division of Endocrinology, Denver

Peter J. Snyder, University of Pennsylvania School of Medicine, Philadelphia

17. Other Piuitary Lesions

Stephen A. Geller, UCLA, School of Medicine, Los Angeles

Section 4 Pituitary Disease in Systemic Disorders

18. Pituitary Function in Systemic Disorders

William F. Chandler, University of Michigan, Pituitary and Neuroendocrine Center, Ann Arbor

19. The Pituitary Gland in Pregnancy and the Puerperium

Errol R. Norwitz, Yale University School of Medicine, Division of Maternal-Fetal Medicine, New Haven

20. Drugs and Pituitary Function

Elizabeth Ginsberg, Brigham and Women's Hospital, Harvard University Medical School

Section 5 Diagnostic Procedures

21. Pituitary Imaging

Barry D. Pressman, Cedars-Sinai Medical Center, Chief, Section of Neuroradiology and Chairman, Department of Imaging, Los Angeles

22. Neuro-ophthalmologic Evaluation of Pituitary Disorders

Anthony C. Arnold, UCLA, Department of Opthalmology, Los Angeles

23. Evaluation of Normal Pituitary Function

Gillian L. Booth, Department of Medicine, University of Toronto, Canada