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Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.

Handbook of the Biology of Aging

1. Understanding Aging Through Conserved Longevity Pathways 2. Role of the somatotropic Axis in Mammalian Aging 3. Mitochondria in aging: Dysfunction 4. Aging of Stem Cells: Intrinsic Changes and Environmental Influences 5. Telomeres and Telomere Dysfunction in Aging 6. mTOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species 7. Sirtuins in Aging and Age-Related Diseases 8. Protein Homeostasis and Aging 9. Genetics of Human Aging 10. Calorie Restriction in Nonhuman and Human Primates 11. Terminal Weight Loss, Frailty, and Mortality 12. Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction 13. Aging and Adipose Tissue 14. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Intervention 15. Aging and Insulin Secretion 16. Cardiovascular Effects of Aging in Primates-Gender Differences 17. Cerebral Vascular Dysfunction with Aging 18. Pulmonary Function in Aging Humans 19. Bone Aging 20. Age-Related Changes in Thermoreception and Thermoregulation 21. Sex Differences in Longevity and Aging 22. Inflammation in Aging Processes: An Integrative and Ecological Perspective 23. Systems Biology Approaches to Understanding Aging 24. Evolutionary Biology of Aging 25. Epigenetic Control of Longevity 26. An Objective Appraisal of the Free Radical Theory of Aging 27. Aging Research: Promise and Pitfalls