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Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner.

"..a spectacular and seemingly comprehensive review of rheumatology." Reviewed by Dr. Harry Brown, on behalf of glycosmedia.com, December 2014

Rheumatology, 2 Vols.: Expert Consult: Online and Print

Section 1: The Scientific Basis of Rheumatic Disease

1. Epidemiologic concepts and the classification of rheumatic and musculoskeletal conditions

2. Principles of clinical outcome assessment

3. Principles of health economics and application to rheumatic disorders

4. The synovium

5. The articular cartilage

6. Bone structure and function

7. Tendons and ligaments

8. Connective tissue responses to mechanical stresses

9. Biomechanics of peripheral joints

10. Biomechanics of the spine

11. Principles of genetic epidemiology

12. Principles and techniques in molecular biology

13. Cytokines

14. Signal transduction in immune cells

15. The principles of adaptive immunity

16. Principles of innate immunity

17. Systems biology

18. Epigenetics in Rheumatology

19. The microbiome in rheumatic diseases

20. Tissue destruction and repair

21. Principles of tissue engineering and cell- and gene-based therapy

22. Osteoimmunology

23. Inflammation and its mediators

24. Scientific basis of pain

25. Effects of the neuroendocrine system on development and function of the immune system

26. Interpreting the medical literature for the rheumatologist: study design and levels of evidence

27. Ethics in clinical trials

Section 2: Clinical Basis of Rheumatic Disease

28. History and physical examination

29. Pattern recognition in arthritis

30. Role of laboratory tests in rheumatic disorders

31. Synovial fluid analysis

32. Minimally invasive procedures

33. Skin in rheumatic disease

34. The eye in rheumatic disease

35. The heart in rheumatic disease

36. The lung in rheumatic disease

37. Gastrointestinal tract and rheumatic disease

38. The kidney and rheumatic disease

39. The nervous system in rheumatic disease

Section 3: Evaluation: Imaging Techniques

40. Conventional radiography and computed tomography

41. Functional magnetic resonance imaging

42. Musculoskeletal ultrasound

43. Bone scintigraphy and positron emission tomography

44. Dual x-ray absorptiometry and measurement of bone

45. Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials

Section 4: Principles of Management

46. Arthritis patient education, health promotion, and team approaches to management

47. Principles of rehabilitation: physical and occupational therapy

48a. Complementary and alternative medicine

48b. Placebos, Caring and Healing in Rheumatology

49. Drug Development

50. Non-pharmacologic pain management

51. Pharmacogenomics in rheumatology

52. Principles of opioid treatment of chronic musculoskeletal pain

53. Non-steroidal anti-inflammatory drugs

54. Systemic glucocorticoids in rheumatology

55. Nonimmunosuppresive disease-modifying antirheumatic drugs

56. Methotrexate

57. Leflunomide

58. Immunosuppressives: cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil

59. T-cell costimulation and other directed therapies

60. B-Cell depletion

61. Cytokine neutralizers: interleukin-1 inhibitors

62. Interleukin-6 Inhibition

63. Tumor necrosis factor blocking therapies

64. Kinase inhibition: a new therapeutic principle in rheumatology

65. Emerging therapeutic targets: GM-CSF, IL-17and IL-23

66. Biosimilars in Rheumatology

67. Infections and biologic therapy in rheumatoid arthritis: an update on risk and prevention

68. Drugs and pregnancy

69. Aspiration and injection of joints and periarticular tissues and intralesional therapy

70. Perioperative care of patients with rheumatic disease

Section 5: Regional and Widespread Pain

71. Neck pain

72. Lumbar spine disorders

73. The shoulder

74. The elbow

75. The wrist and hand

76. The hip

77. The knee

78. The ankle and foot

79. The temporomandibular joint

80. Fibromyalgia and related syndrome

81. Entrapment neuropathies and com