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A supplementary course text for upper-undergraduate and graduate students in exercise physiology, exercise biochemistry, and sport nutrition; a reference for professionals in those fields. "This welcome update of the previous edition includes the most recent peer-reviewed literature that examines exercise science in conjunction with the basic sciences. The authors are well-respected scientists in the field and their expertise, in combination with the updated literature, results in a current and trusted information source for this area."

--Doody's Book Review (5-star review)

Biochemistry Primer for Exercise Science

Part I: Proteins and Enzymes: The Basis of Biochemistry



Chapter 1: Amino Acids, Peptides, and Proteins



Nature of Amino Acids



Characteristics of Peptides



Structure of Proteins



Next Stage: Proteomics



Summary



Review Questions



Chapter 2: Enzymes



Enzymes as Catalysts



Rates of Enzymatic Reactions



Enzyme Cofactors



Classification of Enzymes



Protein Transporters



Oxidations and Reductions



Regulation of Enzyme Activity



Measurement of Enzyme Activity



Next Stage: Redox Regulation of the SERCA Pump in Vascular Physiology and Disease



Summary



Review Questions



Chapter 3: Gene Transcription and Protein Synthesis



DNA and RNA



Transcription



Posttranscriptional Modifications of RNA



Translation



Posttranslational Processing of Polypeptides



Protein Degradation



Regulation of Gene Expression in Exercise and Training



Next Stage: MicroRNAs and the Adaptive Response to Exercise Training



Summary



Review Questions



Part II: Metabolism: Regulation and Adaptation to Exercise and Training



Chapter 4: Energy Systems and Bioenergetics



Energy Requirements of Skeletal Muscle



Energy-Rich Phosphates



Energy Systems



Bioenergetics



Next Stage: Epigenetic Control of Skeletal Muscle Fiber Type and Metabolic Potential



Summary



Review Questions



Chapter 5: Oxidative Phosphorylation



Overview of Metabolism



Mitochondria



Citric Acid Cycle



Electron Transport Chain



Coupled Phosphorylation



Regulation of Oxidative Phosphorylation



Quantification of Redox Reactions



Oxidants and Antioxidants



Next Stage: Effects of Aging and Exercise Training on Muscle Mitochondria



Summary



Review Questions



Chapter 6: Carbohydrate and Related Metabolism



Carbohydrates



Cellular Uptake of Glucose



Phosphorylation of Glucose



Glycolysis



Glycogen Metabolism



Lactate Metabolism



Oxidation of Cytoplasmic NADH



Gluconeogenesis



Pentose Phosphate Pathway



Signaling Pathways



Next Stage: Carbohydrate, Exercise Performance, and Fatigue



Summary



Review Questions



Chapter 7: Lipid Metabolism



Types of Lipids



Fat Storage and Metabolism



Oxidation of Fatty Acids



Oxidation of Ketone Bodies



Synthesis of Fatty Acids



Fat as Fuel for Exercise



Metabolism During Exercise: Fat Versus Carbohydrate



Adipose Tissue as an Endocrine Tissue



Cholesterol



Next Stage: Exercise, 24-Hour Fat Oxidation, and Weight Loss



Summary



Review Questions



Chapter 8: Amino Acid and Protein Metabolism



Overview of Amino Acid Metabolism



Degradation of Amino Acids



Urea Cycle



Fate of Amino Acid Carbon Skeletons



Amino Acid Metabolism During Exercise



Additional Roles for Amino Acids



Next Stage: Effects of Diet and Exercise on Protein Degradation and Synthesis



Summary



Review Questions