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Electroporation is the forefront in tumor ablation. This book presents the basic principles and clinical applications of electroporation, including the latest research results and patient data. A comprehensive approach to the basic science behind the development of this ground-breaking technique and its introduction into clinical practice, the book discusses the entire spectrum of currently available reversible treatments, the emerging irreversible applications, and their impact on patient care. Clinical Aspects of Electroporation is the first book intended for clinicians on this extremely important and rapidly developing field.

Clinical Aspects of Electroporation

1) Introductory

1 Introduction to Electroporation
Edward W. Lee, Julie Gehl, Stephen T. Kee
2 Electroporation and cellular physiology
Hanne Gissel, Raphael C. Lee, Julie Gehl
3 The cell in the electric field
Tadej Kotnik, Gorazd Pucihar, Damijan Miklavcic
4 Understanding Electric Fields for Clinical Use
Faisal Mahmood
5 Generators and Applicators - Equipment for Electroporation
Lasse Staal, Richard Gilbert

2)Electrochemotherapy

6 Cell electropermeabilization and cellular uptake of small molecules: the electrochemotherapy concept
Aude Silve, Lluis M. Mir
7 Vascular-disrupting action of electrochemotherapy: mode of action and therapeutic implications
Gregor Sersa, Maja Cemazar
8 Electrochemotherapy of small tumors; the experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) group
Gregor Sersa, Julie Gehl, Jean-Remy Garbay, Declan Soden, Gerald C. O'Sullivan, Louise W. Matthiessen, Marko Snoj, Lluis M. Mir
9 Electrochemotherapy for larger malignant tumors
Louise W. Matthiessen, Tobian Muir, Julie Gehl
10 Cell electroporation in bone tissue
Fini M, Tschon M, Alberghini M, Bianchi G, Mercuri M, Campanacci L, Cavani F, Ronchetti M, De Terlizzi F, Cadossi R
11 Drug and Gene electrotransfer to the brain
Birgit Agerholm-Larsen, Mette Linnert, Helle K. Iversen, Julie Gehl
12 Minimally invasive intraluminal tumor ablation
Patrick F Forde, Michael G Bourke, Slawomir Salwa, Gerald C O' Sullivan, Declan M Soden

3) Gene Electrotransfer

13 Electrotransfer of plasmid DNA
J.M. Escoffre, M.P. Rols, David A. Dean
14 Gene Electrotransfer to Tumor
Loree C. Heller, Richard Heller
15 Gene electrotransfer to lung
David A. Dean
16 Gene electrotransfer to muscle tissue; moving into clinical use
Pernille Hojman17 Gene electrotransfer to skin
Anita Gothelf, Julie Gehl
18 Electroporation-mediated DNA vaccination
Paolo Fagone, Devon J. Shedlock, Stephen Kemmerer , Dietmar Rabussay, David B. Weiner

4) Irreversible Electroporation

19 Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research
Edward W. Lee, Daphne Wong, Stephen T. Kee
20 Translational Research on Irreversible Electroporation - VX2 Rabbit Head and Neck
Daphne Wong, Edward W. Lee, Cassidy H. Tran, Stephen T. Kee
21 Clinical Research on Irreversible Electroporation of the Liver
Ken Thomson, Stephen T. Kee