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Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in man and the lower species, and the mechanisms subserving hormone secretion.

Endocrinology: Basic and Clinical Principles

Part I. Introduction

Introduction to Endocrinology
P. Michael Conn

Part II. Hormone Secretion and Action

Receptors: Molecular Mediators of Hormone Action
Kelly E. Mayo

Second-Messenger Systems and Signal Transduction Mechanisms
Eliot R. Spindel

Steroid Hormones
Derek Henley, Jonathan Lindzey, and Kenneth S. Korach

Plasma Membrane Receptors for Steroid Hormones in Cell Signaling and Nuclear Function
Richard J. Pietras and Clara M. Szego

Growth Factors
Derek LeRoith and William L. Lowe Jr.

Prostaglandins and Leukotrienes: Locally Acting Agents
John A. McCracken

The Neuroendocrine-Immune Interface
Michael S. Harbuz and Stafford L. Lightman

Part III. Insects/Plants/Comparative

Insect Hormones
Lawrence I. Gilbert

Phytohormones and Signal Transduction Pathways in Plants
William Teale, Ivan Paponov, Olaf Tietz, and Klaus Palme

Comparative Endocrinology
Fredrick Stormshak

Part IV. Hypothalamic-Pituitary

Hypothalamic Hormones: GnRH, TRH, GHRH, SRIF, CRH, and Dopamine
Constantine A. Stratakis and George P. Chrousos

Anterior Pituitary Hormones
Ilan Shimon and Shlomo Melmed

Posterior Pituitary Hormones
Daniel G. Bichet

Endocrine Disease: Value for Understanding Hormonal Actions
Anthony P. Heaney and Glenn D. Braunstein

The Pineal Hormone (Melatonin)
Irina V. Zhdanova and Richard J. Wurtman

Thyroid Hormones (T4, T3)
Takahiko Kogai and Gregory A. Brent

Calcium-Regulating Hormones: Vitamin D and Parathyroid Hormone
Geoffrey N. Hendy

Oncogenes and Tumor Suppressor Genes in Tumorigenesis of the Endocrine System
Anthony P. Heaney and Shlomo Melmed

Insulin Secretion and Action
Run Yu, Hongxiang Hui, and Shlomo Melmed

Cardiovascular Hormones
Willis K. Samson and Meghan M. Taylor

Adrenal Medulla (Catecholamines and Peptides)
William J. Raum

Hormones of the Kidney
Masashi Mukoyama and Kazuwa Nakao

Reproduction and Fertility
Neena B. Schwartz

Endocrinology of Fat, Metabolism, and Appetite
Rachel L. Batterham and Michael A. Cowley

Endocrinology of the Ovary
Denis Magoffin, Ashim Kumar, Bulent Yildiz, and Ricardo Azziz

The Testis
Amiya Sinha Hikim, Ronald S. Swerdloff, and Christina Wang

Endocrinology of Aging
Steven W. J. Lamberts

Index