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Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area.The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease.Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets.We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

Membrane Receptors, Channels and Transporters in Pulmonary Circulation

Part I Ion Channels in the Pulmonary Vasculature: Basics and New FindingsThe Role of Ion Channels in Hypoxic Pulmonary VasoconstrictionE. Kenneth Weir, Jésus A. Cabrera, Saswati Mahapatra, Douglas A. Peterson, and Zhigang HongTwo-Pore Domain K+ Channels and Their Role in ChemoreceptionKeith J. BucklerIntricate Interaction Between Store-Operated Calcium Entry and Calcium-Activated Chloride Channelsin Pulmonary Artery Smooth Muscle CellsAbigail S. Forrest, Jeff E. Angermann, Rajesh Raghunathan, Catherine Lachendro, Iain A. Greenwood, and Normand LeblancThe Role of Intracellular Ion Channels in Regulating Cytoplasmic Calciumin Pulmonary Arterial Mmooth Muscle: Which Store and Where?A. Mark EvansCa2+ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle CellsMichael J. Sanderson, Yan Bai, and Jose Perez-ZoghbiPart II TRP Channels in the Pulmonary Vasculature:Basics and New FindingsIntroduction to TRP Channels: Structure, Function, and RegulationMichael Y. Song and Jason X.-J. YuanPhysiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle CellsXiao-Ru Yang, Mo-Jun Lin, and James S. K. ShamThe Contribution of TRPC1 and STIM1 to Capacitative Ca2+ Entry in Pulmonary ArteryLih Chyuan Ng, Judith A. Airey, and Joseph R. HumeStore-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1Donna L. Cioffi, Christina Barry, and Troy StevensTRPM2 Channel Regulates Endothelial Barrier FunctionClaudie M. Hecquet, Gias U. Ahmmed, and Asrar B. MalikPart III Pathogenic Role of Ion Channels in Pulmonary Vascular DiseaseA Proposed Mitochondrial-Metabolic Mechanism for Initiation and Maintenance of Pulmonary Arterial Hypertension in Fawn-Hooded Rats: The Warburg Model of Pulmonary Arterial HypertensionJalees Rehman and Stephen L. ArcherThe Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic PulmonaryVasoconstrictionB.Fuchs, A. Dietrich, T. Gudermann, H. Kalwa, F. Grimminger, and N. WeissmannDevelopmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary VasculatureDavid N. CornfieldHypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth MuscleLarissa A. ShimodaCLC-3 Chloride Channels in the Pulmonary VasculatureJoseph R. Hume, Ge-Xin Wang, Jun Yamazaki, Lih Chyuan Ng, and Dayue DuanPart IV Receptors and Signaling Cascades in Pulmonary Arterial HypertensionRole of Bone Morphogenetic Protein Receptors in the Development of Pulmonary Arterial HypertensionNicholas W. MorrellCross Talk Between Smad, MAPK, and Actin in the Etiology of Pulmonary Arterial HypertensionJames WestNotch Signaling in Pulmonary HypertensionPatricia A. Thistlethwaite, Xiaodong Li, and Xiaoxue ZhangRho Kinase-Mediated Vasoconstriction in Pulmonary HypertensionIvan F. McMurtry, Kohtaro Abe, Hiroki Ota, Karen A. Fagan, and Masahiko OkaThe Serotonin Hypothesis of Pulmonary Hypertension RevisitedMargaret R. MacLean and Yvonne DempsieImpaired Vascular Endothelial Growth Factor Signaling in the Pathogenesis of Neonatal Pulmonary Vascular DiseaseSteven H. AbmanPart V Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary VasoconstrictionMitochondrial Regulation of Oxygen SensingNavdeep S. ChandelReactive Oxygen Species and RhoA Signaling in Vascular Smooth Muscle: Role in Chronic Hypoxia-InducedPulmonary HypertensionThomas C. Resta, Brad R. S. Broughton, and Nikki L. JerniganPolyamine Regulatory Pathways as Pharmacologic Targets in Pulmonary Arterial HypertensionMark N. Gillespie, and Jack W. Olson5-HT Receptors and KV Channel InternalizationAngel Cogolludo and Francisco Perez-VizcainoPart VI Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular DiseaseKCNQ Potassium Channels: New Targets for PulmonaryVasodilator Drugs? Alison M. Gurney, Shreena Joshi, and B