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This volume, The Glycome: Understanding the Diversity and Complexity of Glycobiology, provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research, one largely ignored because of its complexity.





In this volume, the authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process and in disease etiology. It bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker.





The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture.





The authors begin with an introduction to the trends and developments in glycobiology and then proceed to discussing its role in disease pathologies, followed by its roles in other organisms, including bacteria, plants, and as stress busters.





Chapters cover the involvement of the glycome in congenital and noncongenital disorders, the role of glycans in immunological processes, the role of glycans in neurodegeneration and metastasis, the involvement of glycans in host-pathogen interaction, and their role in microbial infection and the immune evasion. The book also provides insights into the therapeutic aspects of acylation as a vital glycosylational modification of proteins. A chapter highlights the scenario of glycans in plants while another discusses glycans as stress coping agents.





The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.

The Glycome: Understanding the Diversity and Complexity of Glycobiology

1. Trends and Advancements in Glycobiology: Towards Development of Glycan-Based Therapeutics





Yaser Rafiq Mir and Raja Amir H. Kuchay











2. Defects in the Human Glycome: Congenital and Non-Congenital Disorders





Mumtaz Anwar











3. Glycome in Immunological Processes: Current Scenario and Future Prospects





Zeba Mueed, Manali Singh, Abhay Mishra, and Nitesh Kumar Poddar











4. Role of Glycans in Neurodegeneration





Abhai Kumar and Smita Singh











5. Glycome in Metastasis: Glycan Remodeling and Tumor Progression





Ayyagari Archana, Durgashree Dutta, Safikur Rahman, and Rinki Minakshi











6. Glycans in the Host-Pathogen Interaction





Muzafar Jan and Sunil K. Arora











7. Glycome in Microbial Infections and Immune Evasion





Abid Qureshi











8. Acylation as a Vital Post-Glycosylation Modification of Proteins: Insights and Therapeutics Prospects





Usma Manzoor, Snowber Shabir Wani, Fasil Ali, Parvaiz A. Dar, and Tanveer Ali Dar











9. Glycome Profiling in Plants: Towards Understanding Scenario of Carbohydrates





Reetika Mahajan, Muslima Nazir, Jahangir A. Dar, Shazia Mukhtar, Muntazir Mushtaq, Susheel Sharma, Jasdeep Chatrath Padaria, Shafiq A. Wani, and Sajad Majeed Zargar











10. Sugars: Coping the Stress in Plants





Ritika Rajpoot