Książki

The book Handheld Total Chemical and Biological Analysis Systems: Bridging NMR, Digital Microfluidics, and Semiconductors centers on the complete design of Nuclear Magnetic Resonance (NMR) microsystems for in vitro chemical and biological assays based on semiconductor chips and portable magnet. Different sensing mechanisms for CMOS in vitro assay are compared, key design criteria of the CMOS transceiver for NMR measurement are revealed, and system-level optimizations of the CMOS NMR platform utilizing digital microfluidic and diverse functions of the CMOS technology are discussed. Two CMOS NMR platforms are implemented, each of these focuses on different aspect of optimization.

Handheld Total Chemical and Biological Analysis Systems: Bridging NMR, Digital Microfluidics, and Semiconductors

Chapter 1Introduction1.1 Overview1.2 Global Necessities for In Vitro Diagnostic Tools1.3 Nuclear Magnetic Resonance for In Vitro Diagnosis1.4 OrganizationReferencesChapter 2State-of-the-Art CMOS In Vitro Diagnostic Devices2.1 Introduction2.2 Transducing Mechanisms of CMOS IVD Tools2.2.1 Electrical-based2.2.2 Optical-based2.2.3 Magnetic-based2.2.4 Mechanical-based2.2.5 NMR-based2.3 In Vitro Diagnostic Applications2.3.1 Immunoassay2.3.2 DNA Hybridization Assay2.3.3 Cell/Bacteria Diagnosis2.4 Discussions and Selection Guide2.4.1 Integration Level2.4.2 Labeling2.4.3 Hardware Preparation2.4.4 Operation2.4.5 Specificityan2.4.6 SummaryReferencesChapter 3 Electronic-Automated Micro-NMR Assay with DMF Device3.1 Introduction3.2 First Prototype: Primary Investigation on NMR-DMF3.2.1 Discrete Electronics and Back-End Signal Processing3.2.2 Magnet3.2.3 RF Coils3.2.4 DMF Device Fabrication and Actuation3.2.5 Experimental Results3.3 Second Prototype: CMOS Micro-NMR Platform with DMF3.3.1 Design and Implementation of CMOS TRX3.3.2 Portable Magnet and RF Coil Co-Design3.3.3 DMF Device and Its Control Circuit3.3.4 Experimental Results3.3.5 Discussion and Outlook3.4 SummaryReferencesChapter 4 One-Chip Micro-NMR Platform with B0-field Stabilization4.1 Introduction4.2 Platform Design4.2.1 Micro-NMR Transceiver4.2.2 Multi-Functional Planar Coil4.2.3 Hall Sensor, Readout Circuit and Current Driver
4.3 Prototype and Experimental Results4.3.1 Experimental Setup and Electrical Measurements4.3.2 Biological/Chemical Measurements4.3.3 Comparison and Discussion4.4 SummaryReferenceChapter 5 Conclusion and Outlook5.1 Summary of Researches5.2 Future ProspectsReferencesAppendix A Modular NMR Electronic Components and MeasurementB DMF Device and ElectronicsC Software and Hardware Interface of Micro-NMR Platform