Książki

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases

Module 1_ Overview of G-Protein coupled receptor.- Chapter 1. General Introduction.- Chapter 2. General Classification.- Chapter 3. Role of GPCR receptors - In development and Physiology.- Chapter 4. Metabotropic Receptors - Sub family and Distribution.- Module 2_ TGR5 receptor.- Chapter 5. Introduction.- Chapter 6. Plasma Membrane receptors [TGR5].- Chapter 7. Nuclear Membrane receptors [FXR].- Chapter 8. Gene expression and signaling pathways of TGR5 receptors.- Chapter 9. Physiological and pathological role of TGR5 receptors.- Chapter 10. Summary.- Module 3_ P2Y receptor.- Chapter 11. Introduction.- Chapter 12. P2Y receptor expression and Regulation.- Chapter 13. Signaling Pathways of P2Y receptors.- Chapter 14. Physiological Role of P2Y.- Chapter 15. P2Y in pathophysiology (Renal, Lungs, Cardiovascular system, Brain, etc).- Chapter 16. Summary.- Module 4_ Therapeutically Targeting TGR5 & P2Y receptors.- Chapter 17. Introduction.- Chapter 18. Agonist and Antagonists of TGR5 & P2Y receptors.- Chapter 19. Pharmacological agents targeting TGR5 and its clinical benefits.- Chapter 20. Pharmacological Agents Targeting P2Y receptors and its clinical benefits.- Chapter 21. Conclusive Summary and Future Perspectives.