Książki

This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.

Zebrafish: A Model for Marine Peptide Based Drug Screening

Chapter 1. Biomedical importance of marine peptides/toxins.- Chapter 1.1. General Introduction peptides/toxins.- Chapter 1.2. Source/extraction of marine peptides.- Chapter 1.3. General Classification.- Chapter 1.4. Structural characterization and sequencing.- Chapter 1.5. Mode of action of marine peptides.- Chapter 1.6. Other beneficial bioactivities of marine peptides.- Chapter 2. Toxicity of peptides in Zebrafish embryos.- Chapter 2.1. Introduction to Zebrafish embryos.- Chapter 2.2. Developmental stages of Zebrafish embryos.- Chapter 2.3. Zebrafish embryo toxicity.- Chapter 2.4. Effect of peptides in Zebrafish embryos.- Chapter 2.5. Summary.- Chapter 3. Teratogenic activity of toxins in Zebrafish model.- Chapter 3.1. Introduction to toxins.- Chapter 3.2. Zebrafish embryo metamorphosis.- Chapter 3.3. Zebrafish embryo toxicity.- Chapter 3.4. Effect of toxins in Zebrafish embryos.- Chapter 3.5. Summary.- Chapter 4. Anticancer properties marine peptides/toxins using Zebrafish model.- Chapter 4.1. Introduction.- Chapter 4.2. In vivo anticancer activity of peptides.- Chapter 4.3. Gene expression and regulation.- Chapter 4.4. Effect of peptides/toxins in pathophysiology (Renal, Liver, Heart, Brain, etc).- Chapter 4.5. Summary.- Chapter 5. Protective effect of marine peptides/toxins in CVD using Zebrafish model.- Chapter 5.1. Introduction.- Chapter 5.2. Induction of CVD in Zebrafish model.- Chapter 5.3. Pharmacological agents targeting marine peptides and its clinical benefits.- Chapter 5.4. Pharmacological agents targeting peptides in receptors of myocardium and its clinical benefits.- Chapter 5.5. Conclusive summary and future challenges and opportunities