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This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease.

Despite being completely curable, tuberculosis is still one of the leading global causes of death.  M. tuberculosis, the causative organism - one of the smartest pathogens known - adopts highly intelligent strategies for survival and pathogenesis. 

Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. 

With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.

Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions

Chapter 1. Molecular and Infection biology of M. tuberculosis.- Chapter 1.1. The new knowledge on the PE_PGRS proteins, eventually extending the summary on PE/PPE.- Chapter 1.2. The PE and PPE family proteins of mycobacteria: What they are upto?- Chapter 1.3. Co-operonic and non-co-operonic PE-PPE genes and their function.- Chapter 1.4. Methyltransferases of Mycobacterium tuberculosis.- Chapter 1.5. Heat shock proteins as drug target.- Chapter 1.6.  Poly- -L-glutamine: a multifunctional molecule in mycobacterial cell wall contributes to biofilm formation, virulence and cell wall integrity.- Chapter 1.7. Celluar stress responses and immunological regulations during M. Tuberculosis infection.- Chapter 2. Pathology and Epidemiology of Tuberculosis-. Chapter 2.1. Nontuberculous mycobacteria as emerging pathogens: challenges in diagnostics, treatment and pathogenicity research.- Chapter 2.2. Mesenchymal stem cells: A hidden arsenal for M.tuberculosis  persistence, resuscitation and reactivation.- Chapter 2.3. Charting the patho-epidemiological interconnectivity between tuberculosis and non-communicable disease.- Chapter 2.4. MDR-TB in Australia and cross-border spread of strains.- Chapter 3. Vaccines, Diagnostics and Clinics.- Chapter 3.1. TB Vaccine: Present and Future Perspective.- Chapter 3.2. Role of nanotechnology in improving M. tuberculosis diagnosis sensitive, faster, cheaper and deployable.- Chapter 3.3. Best Practices in M. tuberculosis Research.