Basic Medical Endocrinology, Fourth Edition provides up-to-date coverage of rapidly unfolding advances in the understanding of hormones involved in regulating most aspects of bodily functions. Topics are approached from the perspective of a physiologist with over 40 years of teaching experience.
This fourth edition is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. Each of the fourteen chapters starts with an overview of the topic and ends with a Suggested Reading list. Initial chapters lay a foundation by presenting basic information and principles of hormone structure, secretion, and actions, and the physiological roles of the principal endocrine glands. Subsequent chapters address the role of the endocrine system in solving such physiological problems as the regulation of the volume and composition of body fluids in the face of changing environmental demands, and the regulation of short- and long-term energy balance. The final chapters deal with the indispensable role of hormones in growth, development and reproduction.
Strikes an excellent balance between systems/organismal level of overview and cellular/molecular analysis
Richly illustrated with over 250 full color figures, descriptive schematic diagrams, and laboratory findings
All chapters have been thoroughly rewritten and updated, including new discussions of adrenal steroid biosynthesis, the parathyroid in osteoporosis, obesity and metabolism, as well as an entirely new chapter on gastrointestinal hormones
Editor has 45 years of experience teaching endocrinology and physiology to medical students at Harvard and UMass
Basic Medical Endocrinology
Table of contents
Chapter 1 Introduction
Biosynthesis of Hormones
Storage and Secretion
Hormones in Blood
Hormone Degradation
Mechanisms of Hormone Action
Specificity
Characteristics of Receptors
Hormonal Actions Mediated by Intracellular Receptors
Hormonal Actions Mediated by Surface Receptors
The G-protein Coupled Receptors
Receptors that Signal through Tyrosine Kinase
Regulation of Hormone Secretion
Negative Feedback
Positive Feedback
Feed Forward
Measurement of Hormones
Immunoassays
Hormone Levels in Blood
Suggested Reading
Chapter 2 Pituitary Gland
Morphology
Physiology of the Anterior Pituitary Gland
Glycoprotein Hormones
Growth Hormone and Prolactin
Adrenocorticotropin Family
Development of the Anterior Pituitary Gland
Regulation of Anterior Pituitary Function
Hypophysiotropic Hormones
Thyrotropin Releasing Hormone (TRH)
Gonadotropin Releasing Hormone
Control of GH Secretion
Corticotropin Releasing Hormone
Dopamine and control of Prolactin Secretion
Secretion and Actions of Hypophysiotropic Hormones
Feedback Control of Anterior Pituitary Function
Physiology of the Posterior
Pituitary
Regulation of Posterior Pituitary Function
Suggested Reading
Chapter 3 Thyroid Gland
Morphology
Thyroid Hormones
Biosynthesis
Iodine Trapping
Thyroglobulin Synthesis
Incorporation of Iodine
Hormone Storage
Secretion
Control of Thyroid Function
Effects of Thyroid-Stimulating Hormone
Effects of the Thyroid-Stimulating Immunoglobulins
Autoregulation of Thyroid Hormone Synthesis
Thyroid Hormones in Blood
Metabolism of Thyroid Hormones
Physiological Effects of Thyroid Hormones
Growth and Maturation
Skeletal System
Central Nervous System
AUTONOMIC NERVOUS SYSTEM
CARDIOVASCULAR SYSTEM
METABOLISM
Oxidative Metabolism and Thermogenesis
Carbohydrate Metaboliism
Lipid Metabolism
Nitrogen Metabolism
Regulation of Thyroid Hormone Secretion
Mechanism of Thyroid Hormone Action
Suggested Reading
Chapter 4 Adrenal Glands
Morphology
Adrenal Cortex
Adrenocortical Hormones
Control of Adrenocortical Hormone Synthesis
Adrenal Steroid Hormones in Blood
Postsecretory Metabolism of Adrenal Cortical Hormones
Physiology of the Mineralocorticoids
Effects of Aldosterone on the Kidney
Regulation of Aldosterone Secretion
Physiology of the Glucocorticoids
Effects on Energy Metabolism
Effects on Water Balance
Effects on Lung DevelopmentGlucocorticoids and Responses to Injury
Adrenocortical Function during Stress
Mechanism of Action of Glucocorticoids
Regulation of Glucocorticoid Secretion
Adrenal Medulla
Biosynthesis of the Medullary Catecholamines
Storage, Release, and Metabolism of Medullary Hormones
Physiological Actions of Medullary Hormones
Regulation Of Adrenal Medullary Function
Suggested Reading
Chapter 5 Principles of Hormonal Integration
Integration of Hormonal Signals at the Cellular and Molecular Level
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