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The HDL Handbook: Biological Functions and Clinical Implications, Third Edition, brings laboratory research in HDL from bench to bedside in a reference format for both researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. Information presented is valuable for the development of clinical trials with the aim of improvement of HDL-C levels and the prevention of cardiovascular events. Highlights of this new edition include the science underpinning HDL metabolism including information on HDL-C metabolism, gene expression, gene-bioactive compounds interaction, and post-translational modifications of gene expression of apo-lipoproteins.

• Includes bench-to-bedside coverage of HDL with thorough coverage of basic science, genetics, epidemiology, and treatment
• Updated to include information on oxidated HDL found in the capillary vessels of patients with diabetes mellitus and/or atherosclerosis
• Presents the latest advances in HDL cholesterol research with international perspectives

The HDL Handbook: Biological Functions and Clinical Implications

1. Molecular Mechanisms of Hyperalphalipoproteinemia 2. CETP Deficiency and Concerns in CETP Inhibitor Development 3. Degenerated HDL and Its Clinical Implications 4. HDL Apoprotein Mimetic Peptides as Antiinflammatory Molecules 5. Reverse Cholesterol Transport in HDL Metabolism: Relevance to Atherosclerosis Progression and Cardiovascular Diseases 6. Role of ATP-Binding Cassette Transporters A1 and G1 in Reverse Cholesterol Transport and Atherosclerosis 7. Sphingosine-1-Phosphate and HDL Metabolism 8. Role of SR-BI in HDL Metabolism 9. Paraoxonase 1 and Its Clinical Relevance 10. MicroRNA Regulation of HDL Homeostasis 11. The Application of Proteomic Techniques in the Study of HDL Particle Characterization and Biomarker Discovery 12. Therapies Targeting HDLc Levels and HDL Function