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The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike.



Authored by the chief architects of the WHO classification in neoplasms of hematopoietic and lymphoid tissue.
Covers the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies.
Confirm or challenge your diagnostic interpretations by comparing specimens to over 1,000 high-quality color images.



Boasts detailed, practical advice from world leaders in hematopathology.
Places an emphasis on pathologic diagnoses, including molecular and genetic testing.
Updated with the most current WHO classifications of hematologic disease, including lymphoma and leukemia and peripheral T-cell lymphomas.
Covers hot topics in hematopathology, such as the latest genetic insights into lymphoma and leukemia; the new nomenclature for myelodysplastic syndromes; new developments on the subject of Grey zone lymphoma; and much more.
Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. There's also a downloadable image bank, and Virtual Microscope Slides are featured in several chapters.

Give your clinicians the best guidance with this comprehensive reference in hematopathology.

Hematopathology

Contents



Part I: TECHNICAL ASPECTS 1. Processing of the Lymph Node Biopsy Specimen 2. Fine Needle Aspiration of Lymph Nodes 3. Collection, Processing, and Examination of Bone Marrow Specimens 4. Immunohistochemistry for the Hematopathology Laboratory 5. Flow Cytometry 6. Molecular Diagnosis in Hematopathology 7. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them



Part II: NORMAL and REACTIVE CONDTIONS of HEMATOPOIETIC TISSUES



8. Normal Lymphoid Organs and Tissues 9. The Reactive Lymphadenopathies 10. The Normal Bone Marrow 11. Evaluation of Anemia, Leukopenia, and Thrombocytopenia 12. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders



Part III: LYMPHOID NEOPLASMS



13. Principles of Classification of Lymphoid Neoplasms



Section 1: Mature B-Cell Neoplasms



14. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia 15. Lymphoplasmacytic Lymphoma and Waldenstroem Macroglobulinemia 16. Hairy Cell Leukemia 17. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen 18. Follicular Lymphoma 19. Extranodal Marginal Zone Lymphoma: MALT Lymphoma 20. Primary Cutaneous B-Cell Lymphomas 21. Nodal Marginal Zone Lymphoma 22. Mantle Cell Lymphoma 23. Diffuse Large B-Cell Lymphoma 24. Burkitt Lymphoma and its Mimics 25. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma 26. Plasma Cell Neoplasms 27. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma 28. Classical Hodgkin's Lymphoma and Related Lesions 29. Virally Associated B-Cell Lymphoproliferative Disease



Section 2: MATURE T-CELL AND NK-CELL NEOPLASMS



30. Virally Associated T-Cell and NK-Cell Neoplasms 31. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations 32. T-Cell Prolymphocytic Leukemia 33. Adult T-Cell Leukemia/Lymphoma 34. Hepatosplenic T-Cell Lymphoma 35. Peripheral T-Cell Lymphoma, Not Otherwise Specified 36. Angioimmunoblastic T-Cell Lymphoma 37. Anaplastic Large-Cell Lymphoma, ALK Positive and ALK Negative 38. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas 39. Mycosis Fungoides and Sezary Syndrome 40. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders 41. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes



Section 3: Precursor B- and T-Cell Neoplasms



42. Precursor B- and T-Cell Neoplasms 43. Acute Leukemias of Ambiguous Lineage



Part IV: MYELOID NEOPLASMS



44. Principles of Classification of Myeloid Neoplasms 45. The Myelodysplastic Syndromes 46. Acute Myeloid Leukemia 47. Myeloproliferative Neoplasms 48. Myelodysplastic/Myeloproliferative Neoplasms 49. Mastocytosis 50. Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2 51. Blastic Plasmacytoid Dendritic Cell Neoplasm



Part V: HISTIOCYTIC PROLIFERATIONS



52. Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow 53. Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma



Part VI: IMMUNODEFICIENCY DISORDERS



54. The Pathology of Primary Immunodeficiencies 55. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder



Part VII: SITE-SPECIFIC ISSUES in the DIAGNOSIS of LYMPHOMA and LEUKEMIA



56. Bone Marrow Evaluation for Lymphoma 57. Evaluation of the Bone Marrow After Therapy 58. Non-Hematopoietic Neoplasms of the Bone Marrow 59. Nonlymphoid Lesions of the Lymph Nodes 60. Spleen: Normal Architecture and Neoplastic and Nonneoplastic Lesions 61. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin