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Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases.

• An ideal balance of the basic science you need to know and how to apply that information to clinical practice.
• An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes.
• Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.

• Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases.
• New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies.
• More schematic diagrams clearly summarize information and facilitate understanding.

Kelley and Firestein's Textbook of Rheumatology

• Cover image


• Title Page


• Table of Contents


• Copyright


• Dedication


• Acknowledgement


• Contributors


• Preface


• Volume 1


• Part I Structure and Function of Bone, Joints, and Connective Tissue


• Chapter 1 Biology of the Normal Joint


• Classification of Joints


• Developmental Biology of the Diarthrodial Joint


• Interzone Formation and Joint Cavitation


• Cartilage Formation and Endochondral Ossification


• Development of the Joint Capsule and Synovium


• Development of Nonarticular Joints


• Development of Articular Cartilage


• Organization and Physiology of the Mature Joint


• Synovium


• Joint Innervation


• Tendons


• Ligaments


• Bursae


• Menisci


• Mature Articular Cartilage


• Subchondral Bone


• Synovial Fluid and Nutrition of Joint Structures


• Generation and Clearance of Synovial Fluid


• Synovial Fluid as an Indicator of Joint Function


• Lubrication and Nutrition of the Articular Cartilage


• Conclusion


• References


• Chapter 2 Synovium


• Structure


• Function


• Conclusion


• References


• Chapter 3 Cartilage and Chondrocytes


• Cartilage Structure


• Structure-Function Relationships of Cartilage Matrix Components


• Structure, Classification, and Normal Function of Chondrocytes


• Culture Models for Studying Chondrocyte Metabolism


• Interactions of Chondrocytes with the Extra-cellular Matrix


• Angiogenic and Antiangiogenic Factors


• Roles of Growth and Differentiation (Anabolic) Factors in Normal Cartilage Metabolism


• Role of the Chondrocyte in Cartilage Disease


• Role of the Chondroc