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For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.



Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.
Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.
Includes regular updates online for the life of the edition.
Features more than 1,500 high-quality, full-color photographs-with hundreds new to this edition.
Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases: 2-Volume Set

I Basic Principles in the Diagnosis and Management of Infectious Diseases

A MICROBIAL PATHOGENESIS

1 A Molecular Perspective of Microbial Pathogenicity

2 The Human Microbiome of Local Body Sites and Their Unique Biology

3 Prebiotics, Probiotics, and Synbiotics

B HOST DEFENSE MECHANISMS

4 Innate (General or Nonspecific) Host Defense Mechanisms

5 Adaptive Immunity: Antibodies and Immunodeficiencies

6 Cell-Mediated Defense Against Infection

7 Mucosal Immunity

8 Granulocytic Phagocytes

9 Complement and Deficiencies

10 Human Genetics and Infection

11 Nutrition, Immunity, and Infection

12 Evaluation of the Patient With Suspected Immunodeficiency

C EPIDEMIOLOGY OF INFECTIOUS DISEASE

13 Applied Epidemiology for the Infectious Diseases Physician

14 Emerging and Reemerging Infectious Disease Threats

15 Bioterrorism: An Overview

D CLINICAL MICROBIOLOGY

16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation

E ANTIINFECTIVE THERAPY

17 Principles of Antiinfective Therapy

18 Molecular Mechanisms of Antibiotic Resistance in Bacteria

19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents

20 Penicillins and ss-Lactamase Inhibitors

21 Cephalosporins

22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam

23 Antibiotic Allergy

24 Fusidic Acid

25 Aminoglycosides

26 Tetracyclines, Glycylcyclines, and Chloramphenicol

27 Rifamycins

28 Metronidazole

29 Macrolides and Clindamycin

30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)

31 Daptomycin and Quinupristin-Dalfopristin

32 Polymyxins (Polymyxin B and Colistin)

33 Linezolid, Tedizolid, and Other Oxazolidinones

34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole

35 Quinolones

36 Unique Antibacterial Agents

37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine

38 Topical Antibacterials

39 Antimycobacterial Agents

40A Antifungal Agents: Amphotericin B

40B Antifungal Drugs: Azoles

40C Antifungal Drugs: Echinocandins

40D Antifungal Drugs: Flucytosine

41 Antimalarial Drugs

42 Drugs for Protozoal Infections Other Than Malaria

43 Drugs for Helminths

44 Antiviral Agents: General Principles

45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections

46 Antivirals Against Herpesviruses

47 Antiviral Drugs Against Hepatitis Viruses

48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril)

49 Immunomodulators

50 Hyperbaric Oxygen

51 Antimicrobial Stewardship

52 Designing and Interpreting Clinical Studies in Infectious Diseases

53 Outpatient Parenteral Antimicrobial Therapy

54 Tables of Antiinfective Agent Pharmacology

II Major Clinical Syndromes

A FEVER

55 Temperature Regulation and the Pathogenesis of Fever

56 Fever of Unknown Origin

57 The Acutely Ill Patient With Fever and Rash

B UPPER RESPIRATORY TRACT INFECTIONS

58 The Common Cold

59 Pharyngitis

60 Acute Laryngitis

61 Otitis Externa, Otitis Media, and Mastoiditis

62 Sinusitis

63 Epiglottitis

64 Infections of the Oral Cavity, Neck, and Head

C PLEUROPULMONARY AND BRONCHIAL INFECTIONS

65 Acute Bronchitis

66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease

67 Acute Pneumonia

68 Pleural Effusion and Empyema

69 Bacterial Lung Abscess

70 Chronic Pneumonia

71 Cystic Fibrosis

D URINARY TRACT INFECTIONS

72 Urinary Tract Infections

E SEPSIS

73 Sepsis and Septic Shock

F INTRAABDOMINAL INFECTIONS

74 Peritonitis and Intraperitoneal Abscesses

75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)

76 Pancreatic Infection

77 Splenic Abscess

78 Appendicitis

79 Diverticulitis and Neutropenic Enterocolitis

G CARDIOVASCULAR INFECTIONS

80 Endocarditis and Intravascular Infections

81 Prosthetic Valve Endocarditis

82 Infections of Nonvalvular Cardiovascular Devices

83 Prevention of Infective Endocarditis

84 Myocarditis and Pericarditis

85 Mediastinitis

H CENTRAL NERVOUS SYSTEM INFECTIONS

86 Approach to the Patient With Central Nervous System Infection

87 Acute Meningitis

88 Chronic Meningitis

89 Encephalitis

90 Brain Abscess

91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis

92 Cerebrospinal Fluid Shunt and Drain Infections

I SKIN AND SOFT TISSUE INFECTIONS

93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections

94 Myositis and Myonecrosis

95 Lymphadenitis and Lymphangitis

J GASTROINTESTINAL INFECTIONS AND FOOD POISONING

96 Syndromes of Enteric Infection

97 Esophagitis

98 Diarrhea With Little or No Fever

99 Acute Dysentery Syndromes (Diarrhea With Fever)

100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers

101 Foodborne Disease

102 Tropical Sprue and Environmental Enteric Dysfunction

K BONE AND JOINT INFECTIONS

103 Infectious Arthritis of Native Joints

104 Osteomyelitis

105 Orthopedic Implant-Associated Infections

L DISEASES OF THE REPRODUCTIVE ORGANS AND SEXUALLY TRANSMITTED DISEASES

106 Genital Skin and Mucous Membrane Lesions

107 Urethritis

108 Vulvovaginitis and Cervicitis

109 Infections of the Female Pelvis

110 Prostatitis, Epididymitis, and Orchitis

M EYE INFECTIONS

111 Introduction to Eye Infections

112 Microbial Conjunctivitis

113 Microbial Keratitis

114 Endophthalmitis

115 Infectious Causes of Uveitis

116 Periocular Infections

N HEPATITIS

117 Viral Hepatitis

O ACQUIRED IMMUNODEFICIENCY SYNDROME

118 Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome

119 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development

120 Diagnosis of Human Immunodeficiency Virus Infection

121 The Immunology of Human Immunodeficiency Virus Infection

122 General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases)

123 Pulmonary Manifestations of Human Immunodeficiency Virus Infection

124 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection

125 Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections

126 Human Immunodeficiency Virus Infection in Women

127 Pediatric Human Immunodeficiency Virus Infection

128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection

129 Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection

P MISCELLANEOUS SYNDROMES

130 Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease)

III Infectious Diseases and Their Etiologic Agents

A VIRAL DISEASES

131 Biology of Viruses and Viral Diseases

132 Orthopoxviruses Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox

133 Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses

134 Introduction to Herpesviridae

135 Herpes Simplex Virus

136 Chickenpox and Herpes Zoster (Varicella-Zoster Virus)

137 Cytomegalovirus

138 Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus-Associated Malignant Diseases, and Other Diseases)

139 Human Herpesvirus Types 6 and 7 (Exanthem Subitum)

140 Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)

141 Herpes B Virus

142 Adenoviruses

143 Papillomaviruses

144 JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML)

145 Hepatitis B Virus

146 Hepatitis Delta Virus

147 Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses

148 Orthoreoviruses and Orbiviruses

149 Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses

150 Rotaviruses

151 Alphaviruses (Chikungunya, Eastern Equine Encephalitis)

152 Rubella Virus (German Measles)

153 Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika)

154 Hepatitis C

155 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)

156 Parainfluenza Viruses

157 Mumps Virus

158 Respiratory Syncytial Virus

159 Human Metapneumovirus

160 Measles Virus (Rubeola)

161 Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses

162 Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus)

163 Rabies (Rhabdoviruses)

164 Marburg and Ebola Virus Hemorrhagic Fevers

165 Influenza Viruses, Including Avian Influenza and Swine Influenza

166 California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers

167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses)

168 Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2)

169 Human Immunodeficiency Viruses

170 Introduction to the Human Enteroviruses and Parechoviruses

171 Poliovirus

172 Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70)

173 Parechoviruses

174 Hepatitis A Virus

175 Rhinovirus

176 Noroviruses and Sapoviruses (Caliciviruses)

177 Astroviruses and Picobirnaviruses

178 Hepatitis E Virus

B PRION DISEASES

179 Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases)

C CHLAMYDIAL DISEASES

180 Chlamydia trachomatis (Trachoma and Urogenital Infections)

181 Psittacosis (Due to Chlamydia psittaci)

182 Chlamydia pneumoniae

D MYCOPLASMA DISEASES

183 Mycoplasma pneumoniae and Atypical Pneumonia

184 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species

E RICKETTSIOSES, EHRLICHIOSES, AND ANAPLASMOSES

185 Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses

186 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)

187 Rickettsia akari (Rickettsialpox)

188 Coxiella burnetii (Q Fever)

189 Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)

190 Rickettsia typhi (Murine Typhus)

191 Orientia tsutsugamushi (Scrub Typhus)

192 Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae

F BACTERIAL DISEASES

193 Introduction to Bacteria and Bacterial Diseases

194 Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome)

195 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci

196 Classification of Streptococci

197 Streptococcus pyogenes

198 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis

199 Streptococcus pneumoniae

200 Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species

201 Streptococcus agalactiae (Group B Streptococci)

202 Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci

203 Streptococcus anginosus Group

204 Corynebacterium diphtheriae (Diphtheria)

205 Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci

206 Listeria monocytogenes

207 Bacillus anthracis (Anthrax)

208 Bacillus Species and Related Genera Other Than Bacillus anthracis

209 Erysipelothrix Rhusiopathiae

210 Whipple Disease

211 Neisseria meningitidis

212 Neisseria gonorrhoeae (Gonorrhea)

213 Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci

214 Vibrio cholerae

215 Other Pathogenic Vibrios

216 Campylobacter jejuni and Related Species

217 Helicobacter pylori and Other Gastric Helicobacter Species

218 Enterobacteriaceae

219 Pseudomonas aeruginosa and Other Pseudomonas Species

220 Stenotrophomonas maltophilia and Burkholderia cepacia Complex

221 Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders

222 Acinetobacter Species

223 Salmonella Species

224 Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli

225 Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid)

226 Brucellosis (Brucella Species)

227 Francisella tularensis (Tularemia)

228 Pasteurella Species

229A Plague (Yersinia pestis)

229B Yersinia enterocolitica and Yersinia pseudotuberculosis

230 Bordetella pertussis

231 Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus

232 Legionnaires' Disease and Pontiac Fever

233 Capnocytophaga

234 Bartonella, Including Cat-Scratch Disease

235 Klebsiella granulomatis (Donovanosis, Granuloma Inguinale)

236 Other Gram-Negative and Gram-Variable Bacilli

237 Syphilis (Treponema pallidum)

238 Endemic Treponematoses

239 Leptospira Species (Leptospirosis)

240 Relapsing Fever Caused by Borrelia Species

241 Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi

242 Anaerobic Infections: General Concepts

243 Clostridioides difficile (Formerly Clostridium difficile) Infection

244 Tetanus (Clostridium tetani)

245 Botulism (Clostridium botulinum)

246 Diseases Caused by Clostridium

247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli)

248 Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli

249 Mycobacterium tuberculosis

250 Leprosy (Mycobacterium leprae)

251 Mycobacterium avium Complex

252 Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex

253 Nocardia Species

254 Agents of Actinomycosis

G MYCOSES

255 Introduction to Mycoses

256 Candida Species

257 Aspergillus Species

258 Agents of Mucormycosis and Entomophthoramycosis

259 Sporothrix schenckii

260 Agents of Chromoblastomycosis

261 Agents of Mycetoma

262 Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii)

263 Histoplasma capsulatum (Histoplasmosis)

264 Blastomycosis

265 Coccidioidomycosis (Coccidioides Species)

266 Dermatophytosis (Ringworm) and Other Superficial Mycoses

267 Paracoccidioidomycosis

268 Uncommon Fungi and Related Species

269 Pneumocystis Species

270 Microsporidiosis

H PROTOZOAL DISEASES

271 Introduction to Protozoal Diseases

272 Entamoeba Species, Including Amebic Colitis and Liver Abscess

273 Free-Living Amebae

274 Malaria (Plasmodium Species)

275 Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis

276 Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes

277 Agents of African Trypanosomiasis (Sleeping Sickness)

278 Toxoplasma gondii

279 Giardia lamblia

280 Trichomonas vaginalis

281 Babesia Species

282 Cryptosporidiosis (Cryptosporidium Species)

283 Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species

I DISEASES DUE TO TOXIC ALGAE

284 Human Illness Associated With Harmful Algal Blooms

J DISEASES DUE TO HELMINTHS

285 Introduction to Helminth Infections

286 Intestinal Nematodes (Roundworms)

287 Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis

288 Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes)

289 Tapeworms (Cestodes)

290 Visceral Larva Migrans and Other Uncommon Helminth Infections

K ECTOPARASITIC DISEASES

291 Introduction to Ectoparasitic Diseases

292 Lice (Pediculosis)

293 Scabies

294 Myiasis and Tungiasis

295 Mites, Including Chiggers

296 Ticks, Including Tick Paralysis

L DISEASES OF UNKNOWN ETIOLOGY

297 Kawasaki Disease

IV Special Problems

A NOSOCOMIAL INFECTIONS

298 Infection Prevention and Control in the Health Care Setting

299 Disinfection, Sterilization, and Control of Hospital Waste

300 Infections Caused by Percutaneous Intravascular Devices

301 Nosocomial Pneumonia

302 Health Care-Associated Urinary Tract Infections

303 Health Care-Acquired Hepatitis

304 Transfusion- and Transplantation-Transmitted Infections

B INFECTIONS IN SPECIAL HOSTS

305 Infections in the Immunocompromised Host: General Principles

306 Prophylaxis and Empirical Therapy of Infection in Cancer Patients

307 Infections in Recipients of Hematopoietic Stem Cell Transplants

308 Infections in Solid-Organ Transplant Recipients

309 Infections in Patients With Spinal Cord Injury

310 nfections in Older Adults

311 Infections in Asplenic Patients

312 Infections in Injection Drug Users

313 Surgical Site Infections and Antimicrobial Prophylaxis

C SURGICAL- AND TRAUMA-RELATED INFECTIONS

314 Burns

315 Bites

D IMMUNIZATION

316 Immunization

E ZOONOSES

317 Zoonoses

F PROTECTION OF TRAVELERS

318 Protection of Travelers

319 Infections in Returning Travelers