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To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature.

But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier's full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information.



More than 400 chapters authored by a veritable "Who's Who" of modern medicine
A practical, templated organization with an emphasis on evidence-based references
Thousands of algorithms, figures, and tables that make its information readily accessible
Supplementary videos, heart sounds, and key references
Available in print and on a variety of electronic devices
Supplemented by over 1500 board-style questions and answers to help you prepare for certification and recertification examinations
Continuously updated by Lee Goldman, MD
Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Goldman-Cecil Medicine, 2-Volume Set

SECTION 1: SOCIAL AND ETHICAL ISSUES IN MEDICINE

1. Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession

2. Bioethics in the Practice of Medicine

3. Care of Dying Patients and Their Families

4. Cultural and Social Disparities in Health Care

5. Global Health

SECTION 2: PRINCIPLES OF EVALUATION AND MANAGEMENT

6. Approach to the Patient: History and Physical Examination

7. Approach to the Patient with Abnormal Vital Signs

8. Statistical Interpretation of Data and Using Data for Clinical Decisions

9. Measuring Health and Health Care

10. Quality of Care and Patient Safety

11. Comprehensive Chronic Disease Management

SECTION 3: PREVENTIVE AND ENVIRONMENTAL ISSUES

12. The Periodic Health Examination

13. Physical Activity

14. Adolescent Medicine

15. Immunization

16. Principles of Occupational and Environmental Medicine

17. Radiation Injury

18. Bioterrorism

19. Chronic Poisoning: Trace Metals and Others

SECTION 4: AGING AND GERIATRIC MEDICINE

20. Epidemiology of Aging: Implications of the Aging of Society

21. Geriatric Assessment

22. Common Clinical Sequelae of Aging

23. Urinary Incontinence

24. Neuropsychiatric Aspects of Aging

25. Delirium in the Older Patient

SECTION 5: CLINICAL PHARMACOLOGY

26. Principles of Drug Therapy

27. Pain

28. Biology of Addiction

29. Nicotine and Tobacco

30. Alcohol Use Disorders

31. Drugs of Abuse

32. Synthetic Immunomodulatory Drug Including Glucocorticoids

33. Biologic Agents and Signaling Inhibitors

34. Complementary, Alternative, and Integrative Medicine

SECTION 6: GENETICS

35. Principles of Genetics

36. Clinical Genomics - Genome Structure and Variation

37. Applications of Molecular Technologies to Clinical Medicine

38. Regenerative Medicine, Cell, and Gene Therapies

SECTION 7: PRINCIPLES OF IMMUNOLOGY AND INFLAMMATION

39. The Innate Immune System

40. The Adaptive Immunse System

41. Mechanisms of Immune-Mediated Tissue Injury

42. Mechanisms of Inflammation and Tissue Repair

43. Transplantation Immunology

44. Complement System in Disease

SECTION 8: CARDIOVASCULAR DISEASE

45. Approach to the Patient with Possible Cardiovascular Disease

46. Epidemiology of Cardiovascular Disease

47. Cardiac and Circulatory Function

48. Electrocardiography

49. Echocardiography

50. Noninvasive Cardiac Imaging

51. Catheterization and Angiography

52. Heart Failure: Pathophysiology and Diagnosis

53. Heart Failure: Management and Prognosis

54. Diseases of the Myocardium and Endocardium

55. Principles of Electrophysiology

56. Approach to the Patient with Suspected Arrhythmia

57. Approach to Cardiac Arrest and Life-Threatening Arrhythmias

58. Cardiac Arrhythmias with Supraventricular Origin

59. Ventricular Arrhythmias

60. Electrophysiologic Interventional Procedures and Surgery

61. Congenital Heart Disease in Adults

62. Angina Pectoris and Stable Ischemic Heart Disease

63. Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction

64. ST Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction

65. Interventional and Surgical Treatment of Coronary Artery Disease

66. Valvular Heart Disease

67. Infective Endocarditis

68. Pericardial Diseases

69. Diseases of the Aorta

SECTION 9: VASCULAR MEDICINE

70. Arterial Hypertension

71. Atherosclerotic Peripheral Arterial Disease

72. Other Peripheral Arterial Diseases

73. Thrombotic Disorders: Hypercoagulable States

74. Venous Thrombosis and Embolism

75. Pulmonary Hypertension

76. Antithrombotic and Antiplatelet Therapy

SECTION 10: RESPIRATORY DISEASES

77. Approach to the Patient with Respiratory Disease

78. Imaging in Pulmonary Disease

79. Respiratory Function and Testing

80. Disorders of Ventilatory Control

81. Asthma

82. Chronic Obstructive Pulmonary Disease

83. Cystic Fibrosis

84. Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders

85. Alveolar Filling Disorders

86. Interstitial Lung Disease

87. Occupational Lung Disease

88. Physical and Chemical Injuries of the Lung

89. Sarcoidosis

90. Acute Bronchitis and Tracheitis

91. Overview of Pneumonia

92. Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum

93. Interventional and Surgical Approaches to Lung Disease

SECTION 11: CRITICAL CARE MEDICINE

94. Approach to the Patient in a Critical Care Setting

95. Respiratory Monitoring in Critical Care

96. Acute Respiratory Failure

97. Mechanical Ventilation

98. Approach to the Patient with Shock

99. Cardiogenic Shock

100. Shock Syndromes Related to Sepsis

101. Disorders Due to Heat and Cold

102. Acute Poisoning

103. Medical Aspects of Trauma and Burns

104. Envenomation, Bites, and Stings

105. Rhabdomyolysis

SECTION 12: RENAL AND GENITOURINARY DISEASES

106. Approach to the Patient with Renal Disease

107. Structure and Function of the Kidneys

108. Disorders of Sodium and Water Homeostasis

109. Potassium Disorders

110. Acid-Base Disorders

111. Disorders of Magnesium and Phosphorus

112. Acute Kidney Injury

113. Glomerular Disorders and Nephrotic Syndromes

114. Tubulointerstitial Diseases

115. Diabetes and the Kidney

116. Vascular Disorders of the Kidney

117. Nephrolithiasis

118. Cystic Kidney Diseases

119. Hereditary Nephropathies and Developmental Abnormalities of the Urinary Tract

120. Benign Prostatic Hyperplasia and Prostatitis

121. Chronic Kidney Disease

122. Treatment of Irreversible Renal Failure

SECTION 13: GASTROINTESTINAL DISEASES

123. Approach to the Patient with Gastrointestinal Disease

124. Diagnostic Imaging Procedures in Gastroenterology

125. Gastrointestinal Endoscopy

126. Gastrointestinal Hemorrhage

127. Disorders of Gastrointestinal Motility

128. Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, Esophageal Chest Pain, and Heartburn

129. Diseases of the Esophagus

130. Acid Peptic Disease

131. Approach to the Patient with Diarrhea and Malabsorption

132. Inflammatory Bowel Disease

133. Inflammatory and Anatomic Diseases of the Intestine, Peritoneum, Mesentery, and Omentum

134. Vascular Diseases of the Gastrointestinal Tract

135. Pancreatitis

136. Diseases of the Rectum and Anus

SECTION 14: DISEASES OF THE LIVER, GALLBLADDER, AND BILE DUCTS

137. Approach to the Patient with Liver Disease

138. Approach to the Patient with Jaundice or Abnormal Liver Tests

139. Acute Viral Hepatitis

140. Chronic Viral and Autoimmune Hepatitis

141. Toxin- and Drug-Induced Liver Disease

142. Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases

143. Alcoholic and Nonalcoholic Steatohepatitis

144. Cirrhosis and Its Sequelae

145. Hepatic Failure and Liver Transplantation

146. Diseases of the Gallbladder and Bile Ducts

SECTION 15: HEMATOLOGIC DISEASES

147. Hematopoiesis and Hematopoietic Growth Factors

148. The Peripheral Blood Smear

149. Approach to the Anemias

150. Microcytic and Hypochromic Anemias

151. Autoimmune and Intravascular Hemolytic Anemias

152. Hemolytic Anemias: Red Cell Membrane and Metabolic Defects

153. The Thalassemias

154. Sickle Cell Disease and Other Hemoglobinopathies

155. Megaloblastic Anemias

156. Aplastic Anemia and Related Bone Marrow Failure States

157. Polycythemia Vera, Essential Thrombocythemia, and Primary Myelobfibrosis

158. Leukocytosis and Leukopenia

159. Approach to the Patient with Lymphadenopathy and Splenomegaly

160. Histiocytoses

161. Eosinophilic Syndromes

162. Approach to the Patient with Bleeding and Thrombosis

163. Thrombocytopenia

164. Von Willebrand Disease and Hemorrhagic Abnormalities of Platelet and Vascular Function

165. Hemorrhagic Disorders: Coagulation Factor Deficiencies

166. Hemorrhagic Disorders: Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Deficiency

167. Transfusion Medicine

168. Hematopoietic Stem Cell Transplantation

SECTION 16: ONCOLOGY

169. Approach to the Patient with Cancer

170. Epidemiology of Cancer

171. Cancer Biology and Genetics

172. Myelodysplastic Syndromes

173. The Acute Leukemias

174. The Chronic Lymphocytic Leukemia

175. Chronic Myeloid Leukemias

176. Non-Hodgkin Lymphomas

177. Hodgkin Lymphoma

178. Plasma Cell Disorders

179. Amyloidosis

180. Tumors of the Central Nervous System

181. Head and Neck Cancer

182. Lung Cancer and Other Pulmonary Neoplasms

183. Neoplasms of the Esophagus and Stomach

184. Neoplasms of the Small and Large Intestine

185. Pancreatic Cancer

186. Liver and Biliary Tract Tumors

187. Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis

188. Breast Cancer and Benign Breast Disorders

189. Gynecologic Cancers

190. Testicular Cancer

191. Prostate Cancer

192. Malignant Tumors of Bone, Sarcomas, and Other Soft Tissue Neoplasms

193. Melanoma and Nonmelanoma Skin Cancers

SECTION 17: METABOLIC DISEASES

194. Approach to Inborn Errors of Metabolism

195. Disorders of Lipid Metabolism

196. Glycogen Storage Diseases

197. Lysosomal Storage Diseases

198. Homocystinuria and Hyperhomocysteinemia

199. The Porphyrias

200. Wilson's Disease

201. Iron Overload (Hemochromatosis)

SECTION 18: NUTRITIONAL DISEASES

202. Nutrition's Interface with Health and Disease

203. Protein-Energy Malnutrition

204. Nutrition in Hospitalized Patients

205. Vitamins, Trace Minerals, and Other Micronutrients

206. Eating Disorders

207. Obesity

SECTION 19: ENDOCRINE DISEASES

208. Approach to the Patient with Endocrine Disease

209. Principles of Endocrinology

210. Neuroendocrinology and the Neuroendocrine System

211. Anterior Pituitary

212. Posterior Pituitary

213. Thyroid

214. Adrenal Cortex

215. Adrenal Medulla, Catecholamines, and Pheochromocytoma

216. Diabetes Mellitus

217. Hypoglycemia/Pancreatic Islet Cell Disorders

218. Polyglandular Disorders

219. Neuroendocrine Tumors

220. Sexual Development and Identity

221. The Testis and Male Hypogonadism, Infertility, and Sexual Function

222. Ovaries and Pubertal Development

223. Reproductive Endocrinology and Infertility

SECTION 20: WOMEN'S HEALTH

224. Approach to Women's Health

225. Contraception

226. Common Medical Problems in Pregnancy

227. Menopause

228. Intimate Partner Violence

SECTION 21: DISEASES OF BONE AND MINERAL METABOLISM

229. Approach to the Patient with Metabolic Bone Disease

230. Osteoporosis

231. Osteomalacia and Rickets

232. The Parathyroid Glands, Hypercalcemia, and Hypocalcemia

233. Paget's Disease of Bone

234. Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Disorders of Bone

SECTION 22: DISEASES OF ALLERGY AND CLINICAL IMMUNOLOGY

235. Approach to the Patient with Allergic or Immunologic Disease

236. Primary Immunodeficiency Diseases

237. Urticaria and Angioedema

238. Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy

239. Drug Allergy

240. Mastocytosis

SECTION 23: RHEUMATIC DISEASES

241. Approach to the Patient with Rheumatic Disease

242. Laboratory Testing in the Rheumatic Diseases

243. Imaging Studies in the Rheumatic Diseases

244. Inherited Diseases of Connective Tissue

245. The Systemic Autoinflammatory Diseases

246. Osteoarthritis

247. Bursitis, Tendinitis, and Other Periarticular Disorders and Sports Medicine

248. Rheumatoid Arthritis

249. The Spondyloarthropathies

250. Systemic Lupus Erythematosus

251. Systemic Sclerosis (Scleroderma)

252. Sjoegren's Syndrome

253. Inflammatory Myopathies

254. The Systemic Vasculitides

255. Giant Cell Arteritis and Polymyalgia Rheumatica

256. Infections of Bursae, Joints, and Bones

257. Crystal Deposition Diseases

258. Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain

259. Systemic Diseases in Which Arthritis Is a Feature

260. Surgical Treatment of Joint Diseases

SECTION 24: INFECTIOUS DISEASES

261. Introduction to Microbial Disease: Pathophysiology and Diagnostics

262. The Human Microbiome

263. Principles of Anti-Infective Therapy

264. Approach to Fever or Suspected Infection in the Normal Host

265. Approach to Fever and Suspected Infection in the Compromised Host

266. Prevention and Control of Health Care-Associated Infections

267. Approach to the Patient with Suspected Enteric Infection

268. Approach to the Patient with Urinary Tract Infection

269. Approach to the Patient with a Sexually Transmitted Infection

270. Approach to the Patient before and after Travel

271. Antibacterial Chemotherapy

272. Staphylococcal Infections

273. Streptococcus Pneumoniae Infections

274. Nonpneumococcal Streptococcal Infections and Rheumatic Fever

275. Enterococcal Infections

276. Diphtheria and Other Corynebacteria Infections

277. Listeriosis

278. Anthrax

279. Erysipelothrix Infections

280. Clostridial Infections

281. Diseases Caused by Non-Spore-Forming Anaerobic Bacteria

282. Neisseria Meningitidis Infections

283. Neisseria Gonorrhoeae Infections

284. Haemophilus and Moraxella Infections

285. Chancroid

286. Cholera and Other Vibrio Infections

287. Campylobacter Infections

288. Escherichia Coli Enteric Infections

289. Infections due to Other Members of the Enterobacteriaceae, including Management of Multidrug Resistant Strains

290. Pseudomonas and Related Gram-Negative Bacillary Infections

291. Diseases Caused by Acinetobacter and Stenotrophomonas Species

292. Salmonella Infections (including Typhoid Fever)

293. Shigellosis

294. Brucellosis

295. Tularemia and Other Francisella Infections

296. Plague and Other Yersinia Infections

297. Whooping Cough and Other Bordetella Infections

298. Legionella Infections

299. Bartonella Infections

300. Granuloma Inguinale (Donovanosis)

301. Mycoplasma Infections

302. Diseases Caused by Chlamydiae

303. Syphilis

304. Nonsyphilitic Treponematoses

305. Lyme Disease

306. Relapsing Fever and Other Borrelia Infections

307. Leptospirosis

308. Tuberculosis

309. The Nontuberculous Mycobacteria

310. Leprosy (Hansen Disease)

311. Rickettsial Infections

312. Zoonoses

313. Actinomycosis

314. Nocardiosis

315. Systemic Antifungal Agents

316. Endemic Mycoses

317. Cryptococcosis

318. Candidiasis

319. Aspergillosis

320. Mucormycosis

321. Pneumocystis Pneumonia

322. Mycetoma and Dematiaceous Fungal Infections

323. Antiparasitic Therapy

324. Malaria

325. African Sleeping Sickness

326. Chagas Disease

327. Leishmaniasis

328. Toxoplasmosis

329. Cryptosporidiosis

330. Giardiasis

331. Amebiasis

332. Babesiosis and Other Protozoan Diseases

333. Cestodes

334. Trematode Infections

335. Nematode Infections

336. Antiviral Therapy (Non-HIV)

337. The Common Cold

338. Respiratory Syncytial Virus

339. Parainfluenza Viral Disease

340. Influenza

341. Adenovirus Diseases

342. Coronaviruses

343. Measles

344. Rubella (German Measles)

345. Mumps

346. Cytomegalovirus, Epstein-Barr Virus, and Slow Virus Infections of the Central Nervous System

347. Parvovirus

348. Smallpox, Monkeypox, and Other Poxvirus Infections

349. Papillomavirus

350. Herpes Simplex Virus Infections

351. Varicella-Zoster Virus (Chickenpox, Shingles)

352. Cytomegalovirus

353. Epstein-Barr Virus Infection

354. Retroviruses Other Than Human Immunodeficiency Virus

355. Enteroviruses

356. Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses

357. Viral Hemorrhagic Fevers

358. Arboviruses Causing Fever and Rash Syndromes

359. Arboviruses Affecting the Central Nervous System

SECTION 25: HIV AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME

360. Epidemiology of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome

361. Immunopathogenesis of Human Immunodeficiency Virus Infection

362. Biology of Human Immunodeficiency Viruses

363. Prevention of Human Immunodeficiency Virus Infection

364. Antiretroviral Therapy of HIV/AIDS

365. MICROBIAL COMPLICATIONS IN PERSONS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS

366. Systemic Manifestations of HIV/AIDS

367. Immune Reconstitution Inflammatory Syndrome in HIV/AIDS

SECTION 26: NEUROLOGY

368. Approach to the Patient with Neurologic Disease

369. Psychiatric Disorders in Medical Practice

370. Headaches and Other Head Pain

371. Traumatic Brain Injury and Spinal Cord Injury

372. Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord

373. Regional Cerebral Dysfunction: Higher Mental Functions

374. Cognitive Impairment and Dementia

375. The Epilepsies

376. Coma, Vegetative State, and Brain Death

377. Sleep Disorders

378. Approach to Cerebrovascular Diseases

379. Ischemic Cerebrovascular Disease

380. Hemorrhagic Cerebrovascular Disease

381. Parkinsonism

382. Other Movement Disorders

383. Multiple Sclerosis and Demyelinating Conditions of the Central Nervous System

384. Meningitis: Bacterial, Viral, and Other

385. Brain Abscess and Parameningeal Infections

386. Acute Viral Encephalitis

387. Prion Diseases

388. Nutritional and Alcohol-Related Neurologic Disorders

389. Congenital, Developmental, and Neurocutaneous Disorders

390. Autonomic Disorders and Their Management

391. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

392. Peripheral Neuropathies

393. Muscle Diseases

394. Disorders of Neuromuscular Transmission

SECTION 27: EYE, EAR, NOSE, AND THROAT DISEASES

395. Diseases of the Visual System

396. Neuro-Ophthalmology

397. Diseases of the Mouth and Salivary Glands

398. Approach to the Patient with Nose, Sinus, and Ear Disorders

399. Smell and Taste

400. Hearing and Equilibrium

401. Throat Disorders

SECTION 28: MEDICAL CONSULTATION

402. Principles of Medical Consultation

403. Preoperative Evaluation

404. Overview of Anesthesia

405. Postoperative Care and Complications

406. Medical Consultation in Psychiatry

SECTION 29: SKIN DISEASES

407. Approach to Skin Diseases

408. Principles of Therapy of Skin Diseases

409. Eczema, Photodermatoses, Papulosquamous (including Fungal) Diseases, and Figurate Erythemas

410. Macular, Papular, Vesiculobullous, and Pustular Diseases

411. Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases

412. Infections, Hyperpigmentation and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin

413. Diseases of Hair and Nails