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For over fifty years, this volume has remained the definitive reference work in the field of arterial hemodynamics, covering arterial structure and function with special emphasis on pulsatile flow and pressure. The sixth edition continues to provide the theoretical basis required for a thorough understanding of arterial blood flow in both normal and pathological conditions, while keeping clinical considerations and readability paramount throughout the text. With an abundance of illustrations to clarify key principles, the book discusses arterial biomarkers, atherosclerosis, specific arterial disease, generalized and metabolic disease, and therapeutic strategies.

McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles

The nature of flow of a liquid. Properties of the arterial wall: theory. Properties of the arterial wall: practice. Endothelial function. General principles for measuring arterial waves. Pulsatile pressure-flow relations. Ultrasound. Wave reflections. Contours of pressure and flow waves in arteries. Principles of recording and analysis of arterial waveforms. Vascular impedance. Aortic input impedance as ventricular load. Coupling of the left ventricle with the systemic circulation: implications to cardiac failure. Cardiac failure: clinical implications. The pulmonary circulation. The coronary circulation. Special circulations. Aging. Hypertension. Interpretation of blood pressure in epidemiological studies and clinical trials. Arterial biomarkers. Atherosclerosis. Specific arterial disease. Generalized and metabolic disease. Therapeutic strategies. Exercise. Central arterial pressure. Lifestyle and environment. Pressure pulse waveform analysis.