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Current Topics in Medical Mycology, is intended to summarize current research areas in medical mycology for medical my cologists and other scientists who are working in microbiology and immunology. Topics to be included in each volume will serve as contemporary reviews, summaries of current advance ments and future directions, and mechanisms to enhance the interdisciplinary use of medically important fungi in under standing pathogenesis, epidemiology, mycotoxins, taxonomy, and other areas where basic, applied, and clinical sciences are used. Michael R. McGinnis v Contents Series Preface v Contributors ix Ultrastructural Correlates of Antimycotic Treatment MARCEL BORGERS 2 Soluble Polysaccharides of Cryptococcus neoformans ROBERT CHERNIAK 40 3 Tinea Imbricata RODERICK J. HAY 55 4 Adhesion and Association Mechanisms of Candida albicans MICHAEL J. KENNEDY 73 5 Peptide Transport in Candida albicans: Implications for the Development of Antifungal Agents FRED NAIDER and JEFFREY M. BECKER 170 6 Epidemiology of Coccidioidomycosis DEMOSTHENES PAPPAGIANIS 199 7 Immune Response to Paracoccidioides brasiliensis in Human and Animal Hosts ANGELA RESTREPO M. 239 vii Vlll Contents 8 Morphogenetic Transformation of Fungi MAXWELL G. SHEPHERD 278 9 Epidemiology of Nosocomial Fungal Infections DAVID J. WEBER and WILLIAM A. RUTALA 305 Melanins and Their Importance in 10 Pathogenic Fungi MICHAEL H. WHEELER and ALOIS A. BELL 338 11 Cytochrome P-450 of Fungi: Primary Target for Azole Antifungal Agents Yuzo YOSHIDA 388 Index 419 Contributors JEFFREY M. BECKER, Ph.D.

Current Topics in Medical Mycology

1 Ultrastructural Correlates of Antimycotic Treatment.- 2 Soluble Polysaccharides of Cryptococcus neoformans.- 3 Tinea Imbricata.- 4 Adhesion and Association Mechanisms of Candida albicans.- 5 Peptide Transport in Candida albicans: Implications for the Development of Antifungal Agents.- 6 Epidemiology of Coccidioidomycosis.- 7 Immune Response to Paracoccidioides brasiliensis in Human and Animal Hosts.- 8 Morphogenetic Transformation of Fungi.- 9 Epidemiology of Nosocomial Fungal Infections.- 10 Melanins and Their Importance in Pathogenic Fungi.- 11 Cytochrome P-450 of Fungi: Primary Target for Azole Antifungal Agents.