Mims' Microbiology makes it easy for you to learn the microbiology and basic immunology concepts you need to know for your courses and USMLE. Using a clinically relevant, systems-based approach, this popular medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Mims' Microbiology makes this complex subject simple to understand and remember.
Mims' Medical Microbiology: With STUDENT CONSULT Online Access
Table of contents
Preface v
Acknowledgements vi
Contributors vi
Student Consultants vii
A contemporary approach to microbiology xi
Microbes and parasites xi
The context for contemporary medical
microbiology xi
Microbiology past, present and future xii
The approach adopted in this book xiv
SECTION 1 THE ADVERSARIES - MICROBES
1. Microbes as parasites 3
The varieties of microbes 3
Living inside or outside cells 4
Systems of classification 5
2. The bacteria 7
Structure 7
Nutrition 9
Growth and division 10
Gene expression 11
Survival under adverse conditions 16
Mobile genetic elements 16
Mutation and gene transfer 20
The genomics of medically important bacteria 23
3. The viruses 27
Infection of host cells 27
Replication 29
Outcome of viral infection 31
Major groups of viruses 33
4. The fungi 37
Major groups of disease-causing fungi 37
5. The protozoa 41
6. The helminths and arthropods 43
The helminths 43
The arthropods 46
7. Prions 49'Rogue protein' pathogenesis 49
Development, transmission and diagnosis
of prion diseases 50
Prevention and treatment of prion diseases 51
8. The host-parasite relationship 53
The normal flora 53
Symbiotic associations 56
The characteristics of parasitism 58
The evolution of parasitism 59
SECTION 2 THE ADVERSARIES-HOST DEFENCES
9. The innate defences of the body 67
Defence against entry into the body 67
Defences once the microorganism
penetrates the body 68
10. Adaptive responses provide a 'quantum leap'in effective defence 83
The role of antibodies 83
The role of T lymphocytes 86
Extracellular attack on large infectious agents 89
Local defences at mucosal surfaces 90
11. The cellular basis of adaptive immune
responses 95
B- and T-cell receptors 98
Clonal expansion of lymphocytes 98
The role of memory cells 99
Stimulation of lymphocytes 101
Cytokines 102
Regulatory mechanisms 105
Tolerance mechanisms 106
SECTION 3 THE CONFLICTS
12. Background to the infectious diseases 111
Host-parasite relationships 111
Causes of infectious diseases 115
The biologic response gradient 117
13. Entry, exit and transmission 119
Sites of entry 119
Exit and transmission 125
Types of transmission between humans 127
Transmission from animals 132
14. Immune defences in action 137
Complement 137
Acute phase proteins and pattern
recognition receptors 137
Fever 139
Natural killer cells 139
Phagocytosis 139
Cytokines 142
Antibody-mediated immunity 144
Cell-mediated immunity 146
Recovery from infection 149
15. Spread and replication 153
Features of surface and systemic infections 154
Mechanisms of spread through the body 155
Genetic determinants of spread and replication 158
Other factors affecting spread and replication 159
801 777 223
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