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Details the analytical and computational methods used to reveal the three-dimensional structure of proteins and explains how to interpret the information to elucidate protein function. From basic discovery through practical applications of therapeutically driven structural genomics, this book presents a comprehensive overview of the field.

Structural Genomics and High Throughput Structural Biology

Overview of Structural Genomics: Landscape, Premises, and Current Direction. Purifying Protein for Structural Biology. Protein Crystallization: Automation, Robotization and Miniaturization. NMR Spectroscopy in Structural Genomics. High Throughput Protein Crystallography. From Sequence to Function. Comparative Modeling and Structural Proteomics. Ab Initio Modeling. Determining Function from Structure. Retrieval and Validation of Structural Information. Problems in Computational Structural Proteomics. Therapeutically-Driven Structural Genomics.