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This extensively updated new edition provides an indispensable account of modern in-vitro fertilization practice, building upon the popularity of previous editions. The authors initially give a comprehensive review of the biology of human gametes and embryos, before outlining basic to advanced IVF techniques. New developments in practical techniques and understanding are discussed, including in-vitro maturation, vitrification, preservation of fertility for cancer patients, stem cell technology, preimplantation genetic testing, and the role of epigenetics and imprinting. The revised introduction also incorporates a 'refresher' study review of fundamental principles of cell and molecular biology, now updated with current knowledge of meiosis in human oocytes, embryo metabolism and basic principles of genome editing. With high-quality illustrations and extensive, up-to-date reading lists, it is a must-have textbook for trainee and practising embryologists, as well as clinicians who are interested in the scientific principles that underpin successful IVF.

In-Vitro Fertilization

Preface; Acknowledgements; 1. Review of cell and molecular biology; 2. Endocrine control of reproduction: controlled ovarian hyperstimulation for ART; 3. Gametes and gametogenesis; 4. Sperm-oocyte interaction; 5. First stages of development; 6. Implantation and early stages of fetal development; 7. Stem cell biology; 8. The clinical in-vitro fertilization laboratory; 9. Quality management in the IVF laboratory; 10. Sperm and ART; 11. Oocyte retrieval and embryo culture; 12. Cryopreservation of gametes and embryos; 13. Micromanipulation techniques; 14. Preimplantation genetic diagnosis; 15. Epigenetics and assisted reproduction with John Huntriss; Index.