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The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy.

Narcolepsy: Pathophysiology, Diagnosis, and Treatment

1. ETIOLOGY OF NARCOLEPSY

Etiology and genetics of human narcolepsy
Emmanuel Mignot

Narcolepsy: autoimmunity or secondary to infection?
Adriano Fontana, Heidemarie Gast, Thomas Birchler

Is narcolepsy a neurodegenerative disorder?
Christelle Peyron

2. NEUROCHEMISTRY OF NARCOLEPSY

The roles of hypocretin/orexin in narcolepsy, Parkinson's disease, and normal behaviour
Jerome Siegel

Histamine in narcolepsy and excessive daytime sleepiness
Seiji Nishino

Dopaminergic substrates underlying hypersomnia, sleepiness, and REM sleep expression
David B. Rye, Amanda A.H. Freeman

The serotoninergic system in sleep and narcolepsy
Chloé Alexandre, Thomas E. Scammell

Sleep homeostasis, adenosine, caffeine, and narcolepsy
Hans-Peter Landolt

Prostaglandin D2: an endogenous somnogen
Yoshihiro Urade, Osamu Hayaishi

3. THE ROLE OF THE HYPOCRETINS IN SLEEP-WAKE REGULATION

The neurobiology of sleep-wake systems: an overview
Pierre-Hervé Luppi, Patrice Fort

The hypocretins/orexins: master regulators of arousal and hyperarousal
Matthew E. Carter, Antoine Adamantidis, Luis de Lecea

Optogenetic probing of hypocretin/orexin regulation of wakefulness
Antoine Adamantidis, Luis de Lecea

Hypocretin/orexin receptor functions in mesopontine systems regulating sleep, arousal and cataplexy
Christopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier

Afferent control of the hypocretin/orexin neurons
Thomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie

The neural basis of sleepiness in narcoleptic mice
Thomas E. Scammell, Chloé Alexandre

Mathematical models of narcolepsy
Cecilia Diniz Behn

4. THE KEY ROLE OF THE HYPOTHALAMUS

The hypothalamus and its functions
Giovanna Zoccoli, Roberto Amici, Alessandro Silvani

The prehistory of orexin/hypocretin and melanin-concentrating hormone neurons of the lateral hypothalamus
Clifford B. Saper

Metabolic influence on the hypocretin/orexin neurons
Denis Burdakov

Endocrine abnormalities in narcolepsy
Thomas Pollmächer. Marietta Keckeis, Andreas Schuld

Appetite and obesity
Alice Engel, Norbert Dahmen

5. REWARD, ADDICTION, EMOTIONS AND THE HYPOCRETIN SYSTEM

Effects of orexin/hypocretin on ventral tegmental area dopamine neurons: an emerging role in addiction
Stephanie L. Borgland

Orexin/hypocretin, drug addiction, and narcolepsy
Ralph J. DiLeone, Maysa Sarhan, Ruth Sharf

Emotional processing in narcolepsy
Sophie Schwartz

Depression in narcolepsy
Michael Lutter

6. REM SLEEP DYSREGULATION AND MOTOR ABNORMALITIES IN NARCOLEPSY

The clinical features of cataplexy
Sebastiaan Overeem

Parasomnias in narcolepsy with cataplexy
Yves Dauvilliers, Régis Lopez

The motor system and narcolepsy: Periodic leg movements and restless leg syndrome
Luigi Ferini Strambi

7. THE BORDERLANDS OF NARCOLEPSY

Spectrum of narcolepsy
Claudio Bassetti

Secondary narcolepsy
Philipp O. Valko, Rositsa Poryazova

Posttraumatic narcolepsy
Christian R. Baumann, Rositsa Poryazova

The hypocretin/orexin system and sleepiness in Parkinson's disease
Rolf Fronczek

Idiopathic hypersomnia
Ramin Khatami

8. THE DIAGNOSIS OF NARCOLEPSY AND THE ASSESSMENT OF FITNESS TO DRIVE

Current diagnostic criteria of adult narcolepsy
Alex Iranzo

The arguments for standardized diagnostic procedures
Geert Mayer

Fitness to drive in narcolepsy
Johannes Mathis

9. TREATMENT OF NARCOLEPSY

Treatment of narcolepsy
Gert Jan Lammers

Treatment of narcolepsy in the childMichel Lecendreux