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The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Focal Controlled Drug Delivery

1. Biodegradable Polymers for Focal Delivery Systems

Wahid Khan, Venu Gopala Swami Challa, Robert Langer, and Abraham J. Domb

2. Implantable Medical Devices

Wahid Khan, Eameema Muntimadugu, Michael Jaffe, and Abraham J. Domb

3. Systemic Targeting Systems-EPR Effect, Ligand Targeting Systems

Prasad V. Pawar, Abraham J. Domb, and Neeraj Kumar

4. Liposomal formulations for Focal and Targeted Drug Delivery in Cancer and Other Diseases

Sean Essex and Vladimir Torchilin

5. Polymer Drug Conjugate in Focal Drug Delivery

Rajan Swami, Dinesh Kumar, Wahid Khan, Ramakrishna Sistla, Nalini Shastri

6. Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs

David Stepensky

7. Treatment of Brain Tumors

Betty M. Tyler, Gustavo Pradilla, Uri Hadelsberg, Hansen Bow, and Henry Brem

8. Intranasal Delivery of Neuropeptide-Loaded Nanoparticles and Their Application to Nervous System Therapeutics

Michael J. Kubek, Abraham J. Domb, Daniel J. Kubek^a, Michael C. Veronesi

9. Focal Drug Delivery in Inner Ear Therapy

Jing Zou

10. Nanotechnology Based Ophthalmic Drug Delivery System

Fahima Dilnawaz and Sanjeeb Kumar Sahoo

11. Site Specific Ocular Nucleic Acid Delivery

Ravi S. Shukla and Kun Cheng

12. Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin

Taís Gratieri and Yogeshvar N. Kalia

13. Local Drug Delivery to the Oral Cavity

Sheeba Qureshi, Wahid Khan, Michael Perez-Davidi, Ervin I Weiss, Nurit Beyth, and Abraham J. Domb

14. Focal Drug Delivery for Management of Oral Infections

Nurit Beyth, Orith Haramaty and David Polak

15. Segmental-Dependent Drug Absorption and Delivery: The Stomach

Omri Wolk and Arik Dahan

16. Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract

Omri Wolk and Arik Dahan

17. Nanotechnology Applications in Local Arterial Drug Delivery

Dipti Deshpande, Azizah Jamal-Allial, Kinjal Sankhe, and Mansoor Amiji

18. Drug Eluting Stents

Wahid Khan, Rajesh Thipparaboina, Shady Farah, Judah Z. Weinberger, and Abraham J. Domb

19. Drug-Eluting Vascular Grafts

Jingjia Han and Peter I. Lelkes

20. Delivery Systems for Lymphatic Targeting

Indu Singh, Rajan Swami, Wahid Khan, and Ramakrishna Sistla

21. Spatio-temporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair

Emil Ruvinov and Smadar Cohen

22. Spatio-temporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair

Emil Ruvinov and Smadar Cohen

23. Polymer Based Drug Delivery Systems for Solid Tumor Treatment

Ariella Shikanov and Abraham J. Domb

24. Topical Nanointerventions for Therapeutic and Cosmeceutical Applications

Vandana B. Patravale and Preshita P. Desai

25. Focal Drug Delivery to the Nail

Sudaxshina Murdan

26. Drug Delivery to Wounds, Burns and Diabetes Related Ulcers

Sonam Jain, Abraham J. Domb, and Neeraj Kumar

27. Vaginal Drug Delivery

Emily A. Krogstad, Michael J. Rathbone, and Kim A. Woodrow

28. Prolonged Duration Local Anesthesia

J. Brian McAlvin and Daniel S. Kohane